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Stephan MT, Irvine DJ. Enhancing Cell therapies from the Outside In: Cell Surface Engineering Using Synthetic Nanomaterials. Nano Today. 2011;6(3):309-325doi: 10.1016/j.nantod.2011.04.001.
Stephan, M. T., & Irvine, D. J. (2011). Enhancing Cell therapies from the Outside In: Cell Surface Engineering Using Synthetic Nanomaterials. Nano today, 6(3), 309-325. https://doi.org/10.1016/j.nantod.2011.04.001
Stephan, Matthias T, and Irvine, Darrell J. "Enhancing Cell therapies from the Outside In: Cell Surface Engineering Using Synthetic Nanomaterials." Nano today vol. 6,3 (2011): 309-325. doi: https://doi.org/10.1016/j.nantod.2011.04.001
Stephan MT, Irvine DJ. Enhancing Cell therapies from the Outside In: Cell Surface Engineering Using Synthetic Nanomaterials. Nano Today. 2011 Jun 01;6(3):309-325. doi: 10.1016/j.nantod.2011.04.001. PMID: 21826117; PMCID: PMC3148657.
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Nano Today. 2011 Jun 01;6(3):309-325. doi: 10.1016/j.nantod.2011.04.001.

Enhancing Cell therapies from the Outside In: Cell Surface Engineering Using Synthetic Nanomaterials.

Nano today

Matthias T Stephan, Darrell J Irvine

Affiliations

  1. Department of Material Science and Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.

PMID: 21826117 PMCID: PMC3148657 DOI: 10.1016/j.nantod.2011.04.001

Abstract

Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells.

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