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Sider KL, Blaser MC, Simmons CA. Animal models of calcific aortic valve disease. Int J Inflam. 2011;2011:364310doi: 10.4061/2011/364310.
Sider, K. L., Blaser, M. C., & Simmons, C. A. (2011). Animal models of calcific aortic valve disease. International journal of inflammation, 2011364310. https://doi.org/10.4061/2011/364310
Sider, Krista L, et al. "Animal models of calcific aortic valve disease." International journal of inflammation vol. 2011 (2011): 364310. doi: https://doi.org/10.4061/2011/364310
Sider KL, Blaser MC, Simmons CA. Animal models of calcific aortic valve disease. Int J Inflam. 2011;2011:364310. doi: 10.4061/2011/364310. Epub 2011 Aug 02. PMID: 21826258; PMCID: PMC3150155.
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Int J Inflam. 2011;2011:364310. doi: 10.4061/2011/364310. Epub 2011 Aug 02.

Animal models of calcific aortic valve disease.

International journal of inflammation

Krista L Sider, Mark C Blaser, Craig A Simmons

Affiliations

  1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON, Canada M5S 3G9.

PMID: 21826258 PMCID: PMC3150155 DOI: 10.4061/2011/364310

Abstract

Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. However, many details of the pathobiological mechanisms of CAVD remain to be described, and new approaches to treat CAVD need to be identified. Animal models are emerging as vital tools to this end, facilitated by the advent of new models and improved understanding of the utility of existing models. In this paper, we summarize and critically appraise current small and large animal models of CAVD, discuss the utility of animal models for priority CAVD research areas, and provide recommendations for future animal model studies of CAVD.

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