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Teuling E, Bourgonje A, Veenje S, et al. Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation. PLoS Curr. 2011;3:RRN1255doi: 10.1371/currents.RRN1255.
Teuling, E., Bourgonje, A., Veenje, S., Thijssen, K., de Boer, J., van der Velde, J., Swertz, M., & Nollen, E. (2011). Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation. PLoS currents, 3RRN1255. https://doi.org/10.1371/currents.RRN1255
Teuling, Eva, et al. "Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation." PLoS currents vol. 3 (2011): RRN1255. doi: https://doi.org/10.1371/currents.RRN1255
Teuling E, Bourgonje A, Veenje S, Thijssen K, de Boer J, van der Velde J, Swertz M, Nollen E. Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation. PLoS Curr. 2011 Aug 12;3:RRN1255. doi: 10.1371/currents.RRN1255. PMID: 21915392; PMCID: PMC3166184.
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PLoS Curr. 2011 Aug 12;3:RRN1255. doi: 10.1371/currents.RRN1255.

Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation.

PLoS currents

Eva Teuling, Annika Bourgonje, Sven Veenje, Karen Thijssen, Jelle de Boer, Joeri van der Velde, Morris Swertz, Ellen Nollen

Affiliations

  1. Department of Genetics, University Medical Centre Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen; Groningen Bioinformatics Centre, Nijenborgh 7, 9747 AG Groningen, The Netherlands and Genomics Coordination Center, Department of Genetics, University Medical Center Groningen and Groningen Bioinformatics Center, University of Groningen, P.O. Box 30001, 9700 RB, Groningen, The Netherlands.

PMID: 21915392 PMCID: PMC3166184 DOI: 10.1371/currents.RRN1255

Abstract

Protein aggregation is a common hallmark of a number of age-related neurodegenerative diseases, including Alzheimer's, Parkinson's, and polyglutamine-expansion disorders such as Huntington's disease, but how aggregation-prone proteins lead to pathology is not known. Using a genome-wide RNAi screen in a C. elegans-model for polyglutamine aggregation, we previously identified 186 genes that suppress aggregation. Using an RNAi screen for human orthologs of these genes, we here present 26 human genes that suppress aggregation of mutant huntingtin in a human cell line. Among these are genes that have not been previously linked to mutant huntingtin aggregation. They include those encoding eukaryotic translation initiation, elongation and translation factors, and genes that have been previously associated with other neurodegenerative diseases, like the ATP-ase family gene 3-like 2 (AFG3L2) and ubiquitin-like modifier activating enzyme 1 (UBA1). Unravelling the role of these genes will broaden our understanding of the pathogenesis of Huntington's disease.

References

  1. J Neurosci. 2003 Dec 17;23(37):11653-61 - PubMed
  2. Cell. 1998 Jun 12;93(6):973-83 - PubMed
  3. Mol Biol Cell. 2007 Sep;18(9):3582-90 - PubMed
  4. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2898-903 - PubMed
  5. J Biol Chem. 2009 Feb 27;284(9):5523-32 - PubMed
  6. Cell. 2010 Aug 20;142(4):601-12 - PubMed
  7. Nature. 2006 Sep 7;443(7107):50-5 - PubMed
  8. Neurobiol Dis. 2011 Jul;43(1):4-8 - PubMed
  9. Nat Genet. 2010 Apr;42(4):313-21 - PubMed
  10. Cell. 1997 Sep 19;90(6):1013-21 - PubMed
  11. Nature. 2003 Jan 23;421(6921):373-9 - PubMed
  12. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10417-22 - PubMed
  13. Nat Genet. 1999 Dec;23(4):425-8 - PubMed
  14. Nature. 2007 Aug 9;448(7154):704-8 - PubMed
  15. Mol Cell. 2006 Sep 15;23(6):887-97 - PubMed
  16. PLoS One. 2009 Sep 30;4(9):e7275 - PubMed
  17. Nature. 2004 Mar 25;428(6981):431-7 - PubMed
  18. Neurobiol Dis. 2004 Jun;16(1):202-11 - PubMed
  19. Cell. 1998 Oct 2;95(1):55-66 - PubMed
  20. Am J Pathol. 2009 Apr;174(4):1241-51 - PubMed
  21. Hum Mol Genet. 2010 Jun 15;19(12):2445-55 - PubMed
  22. J Cell Mol Med. 2009 Aug;13(8B):2645-2657 - PubMed
  23. Am J Med Genet. 2001 Jul 8;105(5):399-403 - PubMed
  24. Science. 2000 Mar 10;287(5459):1837-40 - PubMed
  25. Ann Neurol. 2010 Mar;67(3):291-300 - PubMed
  26. Mol Cell Biol. 2007 Jan;27(2):758-67 - PubMed
  27. Autophagy. 2009 Apr;5(3):428-9 - PubMed
  28. Nat Methods. 2006 Sep;3(9):701-6 - PubMed
  29. Mol Cell. 2004 Apr 9;14(1):95-104 - PubMed
  30. Nat Cell Biol. 2006 Oct;8(10):1155-62 - PubMed
  31. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4604-9 - PubMed
  32. Am J Hum Genet. 2009 Nov;85(5):617-27 - PubMed
  33. Nature. 2004 Oct 14;431(7010):805-10 - PubMed
  34. J Neurosci. 1999 Apr 1;19(7):2522-34 - PubMed
  35. Hum Mol Genet. 2006 Jan 1;15(1):33-44 - PubMed
  36. EMBO Mol Med. 2009 Nov;1(8-9):360-70 - PubMed
  37. Genetics. 2010 Apr;184(4):1165-79 - PubMed
  38. J Cell Biol. 2008 Mar 24;180(6):1177-89 - PubMed
  39. Nature. 2000 Nov 2;408(6808):101-6 - PubMed
  40. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6403-8 - PubMed
  41. Nat Genet. 1998 Jun;19(2):148-54 - PubMed
  42. Nat Cell Biol. 2006 Oct;8(10):1163-70 - PubMed
  43. Am J Hum Genet. 2008 Jan;82(1):188-93 - PubMed
  44. Science. 1997 Sep 26;277(5334):1990-3 - PubMed
  45. Science. 2002 Apr 19;296(5567):550-3 - PubMed

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