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Lee YS, Kang JW, Lee YH, et al. ID4 mediates proliferation of astrocytes after excitotoxic damage in the mouse hippocampus. Anat Cell Biol. 2011;44(2):128-34doi: 10.5115/acb.2011.44.2.128.
Lee, Y. S., Kang, J. W., Lee, Y. H., & Kim, D. W. (2011). ID4 mediates proliferation of astrocytes after excitotoxic damage in the mouse hippocampus. Anatomy & cell biology, 44(2), 128-34. https://doi.org/10.5115/acb.2011.44.2.128
Lee, Young Sook, et al. "ID4 mediates proliferation of astrocytes after excitotoxic damage in the mouse hippocampus." Anatomy & cell biology vol. 44,2 (2011): 128-34. doi: https://doi.org/10.5115/acb.2011.44.2.128
Lee YS, Kang JW, Lee YH, Kim DW. ID4 mediates proliferation of astrocytes after excitotoxic damage in the mouse hippocampus. Anat Cell Biol. 2011 Jun;44(2):128-34. doi: 10.5115/acb.2011.44.2.128. Epub 2011 Jun 30. PMID: 21829756; PMCID: PMC3145841.
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Anat Cell Biol. 2011 Jun;44(2):128-34. doi: 10.5115/acb.2011.44.2.128. Epub 2011 Jun 30.

ID4 mediates proliferation of astrocytes after excitotoxic damage in the mouse hippocampus.

Anatomy & cell biology

Young Sook Lee, Joon Won Kang, Young Ho Lee, Dong Woon Kim

Affiliations

  1. Department of Anatomy, School of Medicine, Chungnam National University, Daejeon, Korea.

PMID: 21829756 PMCID: PMC3145841 DOI: 10.5115/acb.2011.44.2.128

Abstract

Inhibitor of DNA binding (ID) proteins bind to and inhibit the function of basic helix-loop-helix transcription factors, including those that regulate proliferation and differentiation during development. However, little is known about the role of ID proteins in glial activation under neuropathological conditions. In this study, we evaluated the expression of ID4 following induction of excitotoxic lesions in mouse brain by kainic acid injection. The number of ID4-expressing astrocytes increased in the CA1 layer of the injured hippocampus until 3 days post-lesion. To analyze the effects of ID4 on cell proliferation, primary astrocytes were transduced with recombinant adenovirus expressing GFP-ID4. Overexpression of ID4 led to increased proliferation of astrocytes. These results suggest that ID4 plays a proliferative role in astrocyte activation after excitotoxin-induced hippocampal neuronal death.

Keywords: Astrocytes; Excitotoxicity; ID4; Kainic acid; Proliferation

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