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Szczawinska-Poplonyk A. An overlapping syndrome of allergy and immune deficiency in children. J Allergy (Cairo). 2011;2012:658279doi: 10.1155/2012/658279.
Szczawinska-Poplonyk, A. (2012). An overlapping syndrome of allergy and immune deficiency in children. Journal of allergy, 2012658279. https://doi.org/10.1155/2012/658279
Szczawinska-Poplonyk, Aleksandra. "An overlapping syndrome of allergy and immune deficiency in children." Journal of allergy vol. 2012 (2012): 658279. doi: https://doi.org/10.1155/2012/658279
Szczawinska-Poplonyk A. An overlapping syndrome of allergy and immune deficiency in children. J Allergy (Cairo). 2012;2012:658279. doi: 10.1155/2012/658279. Epub 2011 Sep 12. PMID: 21918651; PMCID: PMC3171763.
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J Allergy (Cairo). 2012;2012:658279. doi: 10.1155/2012/658279. Epub 2011 Sep 12.

An overlapping syndrome of allergy and immune deficiency in children.

Journal of allergy

Aleksandra Szczawinska-Poplonyk

Affiliations

  1. Department of Pediatric Pneumonology, Allergology and Clinical Immunology, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60-572 Poznan, Poland.

PMID: 21918651 PMCID: PMC3171763 DOI: 10.1155/2012/658279

Abstract

Recurrent airway inflammations in children are an important clinical problem in pediatric practice. An essential challenge is differentiation between allergic background and immune deficiency, which is a difficult task taking into consideration individual predisposition to atopy, immune system maturation in the early childhood, as well as exposition to environmental allergens and microbial antigens. In this paper relationship between selected elements of innate and adaptive immunity, such as pattern-recognition receptors, complement components, dendritic cells, as well as immunoglobulins, and regulatory T lymph cells has been discussed. Particular attention has been paid to these mechanisms of the immune response which, depending on settings and timing of activation, predispose to allergy or contribute to tolerogenic phenotype. In the context of multifactorial conditioning of the innate and adaptive immunity governing the ultimate response and associations between allergy and immune deficiencies, these phenomena should be considered as pathogenetically not precluding, but as an overlapping syndrome.

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