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Langer R, Dinges J, Dobritz M, et al. Sclerosing angiomatoid nodular transformation of the spleen presenting as a rapidly growing tumour in a patient with rectal cancer. BMJ Case Rep. 2009;2009doi: 10.1136/bcr.11.2008.1191.
Langer, R., Dinges, J., Dobritz, M., Brauer, R. B., Perren, A., Becker, K., & Kremer, M. (2009). Sclerosing angiomatoid nodular transformation of the spleen presenting as a rapidly growing tumour in a patient with rectal cancer. BMJ case reports, 2009. https://doi.org/10.1136/bcr.11.2008.1191
Langer, Rupert, et al. "Sclerosing angiomatoid nodular transformation of the spleen presenting as a rapidly growing tumour in a patient with rectal cancer." BMJ case reports vol. 2009 (2009). doi: https://doi.org/10.1136/bcr.11.2008.1191
Langer R, Dinges J, Dobritz M, Brauer RB, Perren A, Becker K, Kremer M. Sclerosing angiomatoid nodular transformation of the spleen presenting as a rapidly growing tumour in a patient with rectal cancer. BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.11.2008.1191. Epub 2009 Sep 15. PMID: 21918654; PMCID: PMC3030094.
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BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.11.2008.1191. Epub 2009 Sep 15.

Sclerosing angiomatoid nodular transformation of the spleen presenting as a rapidly growing tumour in a patient with rectal cancer.

BMJ case reports

Rupert Langer, Julia Dinges, Martin Dobritz, Robert B Brauer, Aurel Perren, Karen Becker, Marcus Kremer

Affiliations

  1. Institute of Pathology, Technische Universität München, Trogerstrasse 18, Munich, 81675, Germany.

PMID: 21918654 PMCID: PMC3030094 DOI: 10.1136/bcr.11.2008.1191

Abstract

A patient with rectal cancer developed a rapidly growing splenic mass 2 years after cancer treatment. Since a metastatic process could not be ruled out, splenectomy was performed, and the tumour emerged as a sclerosing angiomatoid nodular transformation (SANT) of the spleen. SANT is a rare, recently recognised, non-neoplastic vascular lesion of the spleen that radiologically may be difficult to distinguish from vascular splenic lesions such as splenic hamartoma, haemangioma or littoral cell angioma. However, morphologically and immunohistochemically it is separated from those tumours by its unique nodular angiomatoid proliferation pattern. SANT is considered to be a benign lesion. This case is reported because of its important clinical impact for the differential diagnosis of splenic masses. Data regarding growth rates of these lesions are scarce and a growth progression as in this case, that finally led to the indication for splenectomy due to lingering suspicion of malignancy, is novel.

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