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Shepard BD, Badley AD. The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious Diseases. Antiinfect Agents Med Chem. 2009;8(2):87-101doi: 10.2174/187152109787846060.
Shepard, B. D., & Badley, A. D. (2009). The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious Diseases. Anti-infective agents in medicinal chemistry, 8(2), 87-101. https://doi.org/10.2174/187152109787846060
Shepard, Brett D, and Badley, Andrew D. "The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious Diseases." Anti-infective agents in medicinal chemistry vol. 8,2 (2009): 87-101. doi: https://doi.org/10.2174/187152109787846060
Shepard BD, Badley AD. The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious Diseases. Antiinfect Agents Med Chem. 2009 Apr 01;8(2):87-101. doi: 10.2174/187152109787846060. PMID: 21857885; PMCID: PMC3158564.
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Antiinfect Agents Med Chem. 2009 Apr 01;8(2):87-101. doi: 10.2174/187152109787846060.

The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious Diseases.

Anti-infective agents in medicinal chemistry

Brett D Shepard, Andrew D Badley

Affiliations

  1. Mayo Clinic College of Medicine, Division of Infectious Diseases, Rochester, MN, 55905, USA.

PMID: 21857885 PMCID: PMC3158564 DOI: 10.2174/187152109787846060

Abstract

TNF-related apoptosis inducing ligand (TRAIL) is a key mediator of the innate immune response to infection. While TRAIL-mediated apoptosis plays an essential role in the clearance of virus-infected cells, its physiologic role also includes immunosurveilance for cancer cells. Therapeutics that induce TRAIL-mediated apoptosis in cancer cells remain a focus of ongoing investigation in clinical trials, and much has been learned from these studies regarding the efficacy and toxicity of these interventions. These data, combined with data from numerous preclinical studies that detail the important and multifaceted role of TRAIL during infection with human immunodeficiency virus and other viruses, suggest that therapeutic exploitation of TRAIL signaling offers a novel and efficacious strategy for the management of infectious diseases.

References

  1. Curr Pharm Des. 2005;11(7):933-44 - PubMed
  2. J Biol Chem. 2000 Jul 28;275(30):23319-25 - PubMed
  3. J Immunol. 2006 Nov 1;177(9):6227-37 - PubMed
  4. Clin Cancer Res. 2005 Apr 15;11(8):3126-35 - PubMed
  5. Scand J Immunol. 2000 Mar;51(3):244-50 - PubMed
  6. Intervirology. 2007;50(3):224-8 - PubMed
  7. J Immunol. 2000 Oct 15;165(8):4522-7 - PubMed
  8. J Cell Sci. 2002 Apr 15;115(Pt 8):1567-74 - PubMed
  9. Nat Biotechnol. 2005 Apr;23(4):409-11 - PubMed
  10. J Histochem Cytochem. 2004 Jun;52(6):821-31 - PubMed
  11. Immunity. 2001 Dec;15(6):997-1009 - PubMed
  12. J Biol Chem. 1998 Jun 5;273(23):14363-7 - PubMed
  13. Blood. 2001 Aug 1;98(3):795-804 - PubMed
  14. J Biol Chem. 2005 Apr 15;280(15):14507-13 - PubMed
  15. Blood. 2005 Nov 15;106(10):3524-31 - PubMed
  16. Eur J Cancer. 2006 Sep;42(14):2233-40 - PubMed
  17. Neuron. 2005 May 5;46(3):421-32 - PubMed
  18. Immunity. 2003 Jan;18(1):1-6 - PubMed
  19. Science. 1997 Aug 8;277(5327):815-8 - PubMed
  20. PLoS Pathog. 2007 Sep 7;3(9):1281-90 - PubMed
  21. Oncogene. 2003 Jun 19;22(25):3842-52 - PubMed
  22. J Virol. 2002 Feb;76(4):1578-87 - PubMed
  23. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5158-63 - PubMed
  24. J Exp Med. 1997 Oct 20;186(8):1365-72 - PubMed
  25. Curr Biol. 1997 Sep 1;7(9):693-6 - PubMed
  26. Neoplasia. 2002 Jul-Aug;4(4):312-23 - PubMed
  27. Cancer J. 2006 Jul-Aug;12(4):247-9 - PubMed
  28. AIDS. 2005 Jul 22;19(11):1125-33 - PubMed
  29. EMBO J. 1998 Feb 2;17(3):706-18 - PubMed
  30. PLoS Biol. 2005 Jun;3(6):e183 - PubMed
  31. Cancer Res. 2002 Oct 15;62(20):5800-6 - PubMed
  32. J Biol Chem. 2001 Jun 8;276(23):20633-40 - PubMed
  33. Cancer Immunol Immunother. 2006 Jan;55(1):76-84 - PubMed
  34. J Neurosci. 2006 Mar 22;26(12):3299-308 - PubMed
  35. Gastroenterology. 2002 Mar;122(3):659-66 - PubMed
  36. Eur J Immunol. 2002 Aug;32(8):2246-54 - PubMed
  37. J Biol Chem. 1996 May 31;271(22):12687-90 - PubMed
  38. J Transl Med. 2005 May 19;3(1):22 - PubMed
  39. Immunobiology. 2001 Dec;204(5):629-38 - PubMed
  40. FASEB J. 2003 Jan;17(1):94-6 - PubMed
  41. Science. 1989 Jul 21;245(4915):305-8 - PubMed
  42. J Hepatol. 2003 Sep;39(3):414-20 - PubMed
  43. Curr Opin Cell Biol. 1999 Apr;11(2):255-60 - PubMed
  44. Cell Death Differ. 2003 Jan;10(1):66-75 - PubMed
  45. Arch Virol. 2000;145(5):905-20 - PubMed
  46. Br J Cancer. 2005 Apr 25;92(8):1430-41 - PubMed
  47. Biochem J. 1997 Aug 15;326 ( Pt 1):1-16 - PubMed
  48. Cell. 1998 Aug 21;94(4):481-90 - PubMed
  49. Cancer Res. 2005 Dec 15;65(24):11265-70 - PubMed
  50. Immunol Cell Biol. 2006 Feb;84(1):87-98 - PubMed
  51. J Mol Med (Berl). 2007 Sep;85(9):923-35 - PubMed
  52. J Neuroimmunol. 2005 Oct;167(1-2):204-9 - PubMed
  53. Cancer. 1992 Jan 1;69(1):256-60 - PubMed
  54. Nat Cell Biol. 2000 Apr;2(4):241-3 - PubMed
  55. Cell Mol Life Sci. 2004 Aug;61(15):1965-74 - PubMed
  56. J Clin Oncol. 2007 Apr 10;25(11):1390-5 - PubMed
  57. AIDS Res Hum Retroviruses. 2004 Feb;20(2):175-82 - PubMed
  58. Hepatology. 2001 Jul;34(1):3-6 - PubMed
  59. Cell. 2000 Jul 7;102(1):43-53 - PubMed
  60. Oncogene. 2001 Apr 19;20(17):2122-33 - PubMed
  61. J Immunol. 2005 Nov 1;175(9):5586-90 - PubMed
  62. J Clin Invest. 1999 Jul;104(2):155-62 - PubMed
  63. Immunity. 2000 Jun;12(6):599-609 - PubMed
  64. Nat Med. 2002 Aug;8(8):808-15 - PubMed
  65. Science. 1997 Aug 8;277(5327):818-21 - PubMed
  66. Biochemistry. 2000 Feb 1;39(4):633-40 - PubMed
  67. Eur J Immunol. 2001 Nov;31(11):3138-46 - PubMed
  68. J Immunol. 2001 Jan 15;166(2):1314-9 - PubMed
  69. Shock. 2004 Aug;22(2):186-8 - PubMed
  70. Cell Death Differ. 2004 Feb;11(2):203-7 - PubMed
  71. Virology. 2007 Jul 20;364(1):45-54 - PubMed
  72. J Exp Med. 2004 Feb 16;199(4):437-48 - PubMed
  73. J Virol. 1998 Oct;72(10):7992-8001 - PubMed
  74. EMBO J. 1997 Sep 1;16(17):5386-97 - PubMed
  75. Immunol Res. 2006;35(3):249-62 - PubMed
  76. Science. 1997 Apr 4;276(5309):111-3 - PubMed
  77. J Virol. 2003 Sep;77(17):9156-72 - PubMed
  78. Cell Immunol. 2001 Dec 15;214(2):194-200 - PubMed
  79. Nat Med. 1999 Feb;5(2):157-63 - PubMed
  80. Nat Med. 2006 Jun;12(6):693-8 - PubMed
  81. J Virol. 2004 Jun;78(11):6033-42 - PubMed
  82. Cell Res. 2004 Oct;14(5):359-72 - PubMed
  83. J Exp Med. 2001 Mar 5;193(5):651-60 - PubMed
  84. Hepatology. 2005 Dec;42(6):1355-63 - PubMed
  85. J Immunol. 2002 Feb 1;168(3):1356-61 - PubMed
  86. Clin Exp Immunol. 2004 Jul;137(1):139-45 - PubMed
  87. J Exp Med. 1999 May 3;189(9):1451-60 - PubMed
  88. Med Sci Monit. 2005 Nov;11(11):RA337-45 - PubMed
  89. Science. 1999 Jun 11;284(5421):1835-7 - PubMed
  90. Lancet. 2000 Sep 2;356(9232):827-8 - PubMed
  91. Biochem Biophys Res Commun. 2007 Jan 12;352(2):329-34 - PubMed
  92. Biochim Biophys Acta. 2004 Mar 1;1644(2-3):125-32 - PubMed
  93. Immunol Cell Biol. 2005 Oct;83(5):511-9 - PubMed
  94. Exp Dermatol. 2002 Dec;11(6):573-83 - PubMed
  95. Clin Immunol. 2007 May;123(2):121-8 - PubMed
  96. Cancer Res. 2001 Feb 1;61(3):1162-70 - PubMed
  97. Br J Haematol. 2005 Aug;130(4):501-10 - PubMed
  98. J Biol Chem. 2001 Nov 2;276(44):40385-8 - PubMed
  99. J Biol Chem. 2004 Sep 17;279(38):40044-52 - PubMed
  100. J Virol. 2000 Jan;74(1):556-9 - PubMed
  101. Biochem Biophys Res Commun. 2000 Nov 30;278(3):747-52 - PubMed
  102. Science. 1993 Mar 19;259(5102):1749-54 - PubMed
  103. Am J Transplant. 2006 May;6(5 Pt 1):976-85 - PubMed
  104. Clin Cancer Res. 2006 Apr 15;12(8):2640-6 - PubMed
  105. Curr Top Microbiol Immunol. 2003;276:77-101 - PubMed
  106. Oncogene. 2007 Jan 11;26(2):248-57 - PubMed
  107. EMBO J. 1997 Dec 1;16(23):6914-25 - PubMed
  108. Diabetes. 2003 Aug;52(8):1967-75 - PubMed
  109. Cancer Res. 2003 Jan 1;63(1):207-13 - PubMed
  110. J Biol Chem. 2004 Jul 23;279(30):30931-7 - PubMed
  111. J Cell Physiol. 2004 Dec;201(3):331-40 - PubMed
  112. Genes Dev. 2002 Jan 1;16(1):33-45 - PubMed
  113. J Cell Physiol. 2005 Jun;203(3):547-56 - PubMed
  114. J Immunol. 2003 Jul 1;171(1):212-8 - PubMed
  115. Biochem Biophys Res Commun. 1999 Nov 19;265(2):479-83 - PubMed
  116. Blood. 2005 Mar 15;105(6):2458-64 - PubMed
  117. J Biol Chem. 2001 Jun 22;276(25):22522-8 - PubMed
  118. Nature. 1993 Aug 26;364(6440):806-9 - PubMed
  119. Immunol Lett. 2002 Mar 1;80(3):169-79 - PubMed
  120. J Pharmacol Exp Ther. 2001 Oct;299(1):31-8 - PubMed
  121. Methods Enzymol. 2000;322:325-45 - PubMed
  122. J Immunol. 1999 Nov 15;163(10):5358-66 - PubMed
  123. Biochem Biophys Res Commun. 2002 Sep 27;297(3):682-7 - PubMed
  124. Nat Med. 1995 Feb;1(2):129-34 - PubMed
  125. Cell Death Differ. 2005 Jan;12(1):94-7 - PubMed
  126. J Immunol. 1998 Sep 15;161(6):2833-40 - PubMed
  127. J Biol Chem. 2000 Jul 7;275(27):20632-7 - PubMed
  128. Cytokine. 2003 Dec 21;24(6):244-53 - PubMed
  129. Science. 2004 Sep 3;305(5689):1471-4 - PubMed
  130. J Virol. 1993 Apr;67(4):2182-90 - PubMed
  131. J Immunol. 1999 Mar 1;162(5):2597-605 - PubMed
  132. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7000-5 - PubMed
  133. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):10964-7 - PubMed
  134. Immunity. 2004 Dec;21(6):877-89 - PubMed
  135. Cancer Biol Ther. 2004 Nov;3(11):1051-7 - PubMed
  136. Cancer Res. 2004 Dec 1;64(23):8502-6 - PubMed
  137. Cytokine. 1999 Sep;11(9):664-72 - PubMed
  138. Cell. 1997 Feb 7;88(3):355-65 - PubMed
  139. Nat Genet. 1997 Oct;17(2):141-3 - PubMed
  140. J Immunol. 2007 Jan 1;178(1):503-10 - PubMed
  141. Science. 1998 Aug 28;281(5381):1305-8 - PubMed
  142. J Immunol. 1999 Jul 15;163(2):920-6 - PubMed
  143. Clin Immunol. 2006 Jun;119(3):245-51 - PubMed
  144. Immunity. 2000 Jun;12(6):611-20 - PubMed
  145. J Biol Chem. 2001 Feb 2;276(5):3270-8 - PubMed
  146. Cancer Res. 1999 Jun 15;59(12):2770-5 - PubMed
  147. J Biol Chem. 2001 Dec 7;276(49):46639-46 - PubMed
  148. J Exp Med. 2002 Jan 21;195(2):161-9 - PubMed
  149. J Virol. 2001 Nov;75(22):11128-36 - PubMed
  150. J Virol. 2004 Nov;78(22):12297-307 - PubMed
  151. J Immunol. 2001 May 1;166(9):5407-15 - PubMed
  152. Nat Immunol. 2003 Mar;4(3):255-60 - PubMed
  153. Curr Top Microbiol Immunol. 2002;269:273-318 - PubMed
  154. J Biol Chem. 1998 Jan 30;273(5):2926-30 - PubMed
  155. Int J Biochem Cell Biol. 2007;39(7-8):1462-75 - PubMed
  156. Blood. 2001 Oct 15;98(8):2474-81 - PubMed
  157. Nat Med. 2001 Apr;7(4):385-6 - PubMed
  158. Nature. 1997 Jul 17;388(6639):300-4 - PubMed
  159. Hum Pathol. 2005 Oct;36(10):1066-73 - PubMed
  160. Science. 1997 Aug 8;277(5327):768 - PubMed
  161. J Immunol. 2006 Sep 1;177(5):3283-93 - PubMed
  162. J Biol Chem. 1997 Oct 10;272(41):25417-20 - PubMed
  163. J Acquir Immune Defic Syndr. 2004 Jun 1;36(2):671-7 - PubMed
  164. Cell. 2004 Jun 25;117(7):855-8 - PubMed
  165. Nat Med. 2001 Apr;7(4):383-5 - PubMed
  166. Immunity. 1995 Dec;3(6):673-82 - PubMed
  167. Circulation. 2003 May 6;107(17):2250-6 - PubMed
  168. Mol Cell. 2001 Sep;8(3):705-11 - PubMed
  169. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13974-9 - PubMed
  170. Cell. 1998 Aug 21;94(4):491-501 - PubMed
  171. J Exp Med. 2003 Aug 4;198(3):491-6 - PubMed
  172. J Biomed Sci. 2001 May-Jun;8(3):290-6 - PubMed
  173. Front Biosci. 2007 May 01;12:3813-24 - PubMed
  174. Hepatology. 2000 Sep;32(3):523-7 - PubMed
  175. Cancer Res. 2002 Jul 1;62(13):3620-5 - PubMed
  176. J Immunol. 2004 Nov 1;173(9):5652-8 - PubMed
  177. J Virol. 2000 Sep;74(17):8135-9 - PubMed
  178. Clin Cancer Res. 2001 May;7(5):1362-9 - PubMed
  179. Oncogene. 2006 Nov 30;25(56):7333-5 - PubMed
  180. Diabetes. 2003 Sep;52(9):2274-8 - PubMed
  181. Nat Med. 2000 May;6(5):564-7 - PubMed

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