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Kusuma HR, Venkataramana NK, Rao SA, et al. Fulminant hepatic failure after repeated exposure to isoflurane. Indian J Anaesth. 2011;55(3):290-2doi: 10.4103/0019-5049.82696.
Kusuma, H. R., Venkataramana, N. K., Rao, S. A., Naik, A. L., Gangadhara, D., & Venkatesh, K. H. (2011). Fulminant hepatic failure after repeated exposure to isoflurane. Indian journal of anaesthesia, 55(3), 290-2. https://doi.org/10.4103/0019-5049.82696
Kusuma, Halemani R, et al. "Fulminant hepatic failure after repeated exposure to isoflurane." Indian journal of anaesthesia vol. 55,3 (2011): 290-2. doi: https://doi.org/10.4103/0019-5049.82696
Kusuma HR, Venkataramana NK, Rao SA, Naik AL, Gangadhara D, Venkatesh KH. Fulminant hepatic failure after repeated exposure to isoflurane. Indian J Anaesth. 2011 May;55(3):290-2. doi: 10.4103/0019-5049.82696. PMID: 21808406; PMCID: PMC3141158.
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Indian J Anaesth. 2011 May;55(3):290-2. doi: 10.4103/0019-5049.82696.

Fulminant hepatic failure after repeated exposure to isoflurane.

Indian journal of anaesthesia

Halemani R Kusuma, Neelam K Venkataramana, Shailesh Av Rao, Arun L Naik, Ds Gangadhara, Keshavan H Venkatesh

Affiliations

  1. Department of Anaesthesiology & Critical Care, BGS Global Hospitals, Bangalore, Karnataka, India.

PMID: 21808406 PMCID: PMC3141158 DOI: 10.4103/0019-5049.82696

Abstract

Inhalational agents are used routinely for maintenance of anaesthesia. Post anaesthesia hepatic failure has been documented following exposure to halothane. However, there are very few reports of such complications following isoflurane anaesthesia. A 6-year-old child developed fulminant hepatic failure 2 days following craniotomy under general anaesthesia. There was no evidence of viral, autoimmune, or metabolic causes of hepatitis. No other medications known to cause hepatitis, except low dose paracetamol, were administered. The clinical and histological picture of our case is similar to that of halothane hepatitis, which has a significant mortality rate. We report this as a possible fulminant hepatic failure resulting from exposure to isoflurane anaesthesia.

Keywords: Children; fulminant; hepatic failure; isoflurane

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