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Murthy SK, Kar B, Vaya L, et al. FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE. Indian J Psychiatry. 1989;31(4):333-7
Murthy, S. K., Kar, B., Vaya, L., & Murthy, D. S. (1989). FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE. Indian journal of psychiatry, 31(4), 333-7.
Murthy, S K, et al. "FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE." Indian journal of psychiatry vol. 31,4 (1989): 333-7.
Murthy SK, Kar B, Vaya L, Murthy DS. FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE. Indian J Psychiatry. 1989 Oct;31(4):333-7. PMID: 21927411; PMCID: PMC3172024.
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Indian J Psychiatry. 1989 Oct;31(4):333-7.

FRAGILE Xq-27 ASSOCIATED WITH SCHIZOPHRENIA AND FAMILIAL PSYCHOSIS AN A MALE.

Indian journal of psychiatry

S K Murthy, B Kar, L Vaya, D S Murthy

Affiliations

  1. Department of Zoology, School of Sciences, Gujarat University, Ahmedabad-380 009.

PMID: 21927411 PMCID: PMC3172024

Abstract

A 31 years old man with history of familial psychiatric disorder was investigated. Chromosomal analysis in peripheral lymphocyte blood culture showed normal karyotype with 46, XY chromosomal complement. However, the cells treated with 5-Fluoro-deoxy-uridine (FUdR) and Caffeine showed fragile Xq-27 (4.0%) and nonspecific autosomal breakages (42.0%). The present case suggests a probable association between chromosomal fragility and non-mental retardation psychopathology. Further cytogenetic studies in cases with familial psychiatric disorders will enable us with a better understanding of the pathogenesis and further help in counselling the families.

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