Display options
Cite
Thivakaran T, Gamage R, Gooneratne IK. Treatment-related fluctuation in Guillain-Barre syndrome. J Neurosci Rural Pract. 2011;2(2):168-70doi: 10.4103/0976-3147.83585.
Thivakaran, T., Gamage, R., & Gooneratne, I. K. (2011). Treatment-related fluctuation in Guillain-Barre syndrome. Journal of neurosciences in rural practice, 2(2), 168-70. https://doi.org/10.4103/0976-3147.83585
Thivakaran, Thirunavukkarasu, et al. "Treatment-related fluctuation in Guillain-Barre syndrome." Journal of neurosciences in rural practice vol. 2,2 (2011): 168-70. doi: https://doi.org/10.4103/0976-3147.83585
Thivakaran T, Gamage R, Gooneratne IK. Treatment-related fluctuation in Guillain-Barre syndrome. J Neurosci Rural Pract. 2011 Jul;2(2):168-70. doi: 10.4103/0976-3147.83585. PMID: 21897682; PMCID: PMC3159355.
Copy Download .nbib Format: NLM
Share it on

J Neurosci Rural Pract. 2011 Jul;2(2):168-70. doi: 10.4103/0976-3147.83585.

Treatment-related fluctuation in Guillain-Barre syndrome.

Journal of neurosciences in rural practice

Thirunavukkarasu Thivakaran, Ranjanie Gamage, Inuka Kishara Gooneratne

Affiliations

  1. Institute of Neurology, National Hospital of Sri Lanka, Sri Lanka.

PMID: 21897682 PMCID: PMC3159355 DOI: 10.4103/0976-3147.83585

Abstract

Guillain-Barre syndrome (GBS) is usually a monophasic illness but relapses occur. A 55-year-old female with hypertension and vitiligo presented with acute inflammatory demyelinating polyradiculoneuropathy. She improved with immunoglobulin treatment started on day 6 of illness, but relapsed on day 14 warranting repeat immunoglobulin therapy. Thereafter recovery was complete. Her relapse was due to treatment-related fluctuation (TRF). TRF is improvement in the GBS disability scale of at least one grade after completion of immunotherapy followed by worsening of the disability scale of at least one grade within the first 2 months after disease onset. Recurrent GBS and chronic inflammatory demyelinating polyradiculoneuropathy were excluded. During the peak of the illness ANA titres were transiently high. The presence of other medical conditions, predominant proximal weakness and the absence of preceding diarrhea are predictors for TRF seen in this patient. Early treatment and evidence of ongoing immune activation have contributed toward TRF.

Keywords: Relapse of Guillain-Barre syndrome; recurrent Guillain-Barre syndrome; treatment-related fluctuation

References

  1. J Inflamm (Lond). 2010 Aug 08;7:40 - PubMed
  2. Drugs. 2004;64(6):597-610 - PubMed
  3. Arch Neurol. 1988 Mar;45(3):314-5 - PubMed
  4. Muscle Nerve. 1998 Oct;21(10):1327-30 - PubMed
  5. Neurology. 2005 Jul 12;65(1):138-40 - PubMed
  6. Lancet. 1998 Aug 22;352(9128):635-41 - PubMed
  7. J Neurol Neurosurg Psychiatry. 1991 Nov;54(11):957-60 - PubMed
  8. J Neurol Neurosurg Psychiatry. 1998 Feb;64(2):242-4 - PubMed
  9. J Neurol Neurosurg Psychiatry. 2009 Jan;80(1):56-9 - PubMed
  10. J Neurol Sci. 2003 Jun 15;210(1-2):105-8 - PubMed

Publication Types