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Summerfield A, McCullough KC. Dendritic Cells in Innate and Adaptive Immune Responses against Influenza Virus. Viruses. 2009;1(3):1022-34doi: 10.3390/v1031022.
Summerfield, A., & McCullough, K. C. (2009). Dendritic Cells in Innate and Adaptive Immune Responses against Influenza Virus. Viruses, 1(3), 1022-34. https://doi.org/10.3390/v1031022
Summerfield, Artur, and McCullough, Kenneth C. "Dendritic Cells in Innate and Adaptive Immune Responses against Influenza Virus." Viruses vol. 1,3 (2009): 1022-34. doi: https://doi.org/10.3390/v1031022
Summerfield A, McCullough KC. Dendritic Cells in Innate and Adaptive Immune Responses against Influenza Virus. Viruses. 2009 Dec;1(3):1022-34. doi: 10.3390/v1031022. Epub 2009 Nov 24. PMID: 21994580; PMCID: PMC3185519.
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Viruses. 2009 Dec;1(3):1022-34. doi: 10.3390/v1031022. Epub 2009 Nov 24.

Dendritic Cells in Innate and Adaptive Immune Responses against Influenza Virus.

Viruses

Artur Summerfield, Kenneth C McCullough

Affiliations

  1. Institute of Virology and Immunoprophylaxis, Sensemattstrasse 293, CH-3147 Mittelhäusern, Switzerland.

PMID: 21994580 PMCID: PMC3185519 DOI: 10.3390/v1031022

Abstract

Dendritic cells (DC) are major players in both innate and adaptive immune responses against influenza virus. These immune responses, as well as the important interface between the innate and adaptive systems, are orchestrated by specialized subsets of DC, including conventional steady-state DC, migratory DC and plasmacytoid DC. The characteristics and efficacy of the responses are dependent on the relative activity of these DC subsets, rendering DC crucial for the development of both naïve and memory immune responses. However, due to their critical role, DC also contribute to the immunopathological processes observed during acute influenza, such as that caused by the pathogenic H5N1 viruses. Therein, the role of different DC subsets in the induction of interferon type I, pro-inflammatory cytokine and chemokine responses is important for the outcome of interaction between the virus and host immune defences. The present review will present current knowledge on this area, relating to the importance of DC activity for the induction of efficacious humoral and cell-mediated immune responses. This will include the main viral elements associated with the triggering or inhibition of DC activation. Finally, the current knowledge on understanding how differences in various vaccines influence the manner of immune defence induction will be presented.

Keywords: dendritic cells; influenza; innate and adaptive immune responses

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