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Müther N, Noske N, Ehrhardt A. Viral hybrid vectors for somatic integration - are they the better solution?. Viruses. 2009;1(3):1295-324doi: 10.3390/v1031295.
Müther, N., Noske, N., & Ehrhardt, A. (2009). Viral hybrid vectors for somatic integration - are they the better solution?. Viruses, 1(3), 1295-324. https://doi.org/10.3390/v1031295
Müther, Nadine, et al. "Viral hybrid vectors for somatic integration - are they the better solution?." Viruses vol. 1,3 (2009): 1295-324. doi: https://doi.org/10.3390/v1031295
Müther N, Noske N, Ehrhardt A. Viral hybrid vectors for somatic integration - are they the better solution?. Viruses. 2009 Dec;1(3):1295-324. doi: 10.3390/v1031295. Epub 2009 Dec 15. PMID: 21994594; PMCID: PMC3185507.
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Viruses. 2009 Dec;1(3):1295-324. doi: 10.3390/v1031295. Epub 2009 Dec 15.

Viral hybrid vectors for somatic integration - are they the better solution?.

Viruses

Nadine Müther, Nadja Noske, Anja Ehrhardt

Affiliations

  1. Max von Pettenkofer-Institut, Department of Virology, Ludwig-Maximilians-Universität Munich, Pettenkoferstr. 9A, 80336 Munich, Germany.

PMID: 21994594 PMCID: PMC3185507 DOI: 10.3390/v1031295

Abstract

The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based on these findings major improvements in vector design including the development of viral hybrid vectors for somatic integration have been achieved. This review provides a state-of-the-art overview of available hybrid vectors utilizing viruses for high transduction efficiencies in concert with various integration machineries for random and targeted integration patterns. It discusses advantages but also limitations of each vector system.

Keywords: PhiC31 integrase; Sleeping Beauty transposase; adeno-associated virus; adenovirus; herpes simplex virus; hybrid vector; retrovirus; somatic integration; targeted integration; zinc-finger nuclease

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