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Nejmeddine M, Bangham CR. The HTLV-1 Virological Synapse. Viruses. 2010;2(7):1427-47doi: 10.3390/v2071427.
Nejmeddine, M., & Bangham, C. R. (2010). The HTLV-1 Virological Synapse. Viruses, 2(7), 1427-47. https://doi.org/10.3390/v2071427
Nejmeddine, Mohamed, and Bangham, Charles R M. "The HTLV-1 Virological Synapse." Viruses vol. 2,7 (2010): 1427-47. doi: https://doi.org/10.3390/v2071427
Nejmeddine M, Bangham CR. The HTLV-1 Virological Synapse. Viruses. 2010 Jul;2(7):1427-47. doi: 10.3390/v2071427. Epub 2010 Jul 07. PMID: 21994688; PMCID: PMC3185711.
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Viruses. 2010 Jul;2(7):1427-47. doi: 10.3390/v2071427. Epub 2010 Jul 07.

The HTLV-1 Virological Synapse.

Viruses

Mohamed Nejmeddine, Charles R M Bangham

Affiliations

  1. Department of Immunology, Wright-Fleming Institute, Imperial College London, St. Mary's campus, Norfolk Place W2 1PG, London, UK.

PMID: 21994688 PMCID: PMC3185711 DOI: 10.3390/v2071427

Abstract

Human T-lymphotropic virus-1 (HTLV-1) spreads efficiently between T-cells via a tight and highly organized cell-cell contact known as the virological synapse. It is now thought that many retroviruses and other viruses spread via a virological synapse, which may be defined as a virus-induced, specialized area of cell-to-cell contact that promotes the directed transmission of the virus between cells. We summarize here the mechanisms leading to the formation of the HTLV-1 virological synapse and the role played by HTLV-1 Tax protein. We propose a model of HTLV-1 transmission between T-cells based on the three-dimensional ultrastructure of the virological synapse. Finally, in the light of recent advances, we discuss the possible routes of HTLV-1 spread across the virological synapse.

Keywords: HTLV-1 virological synapse; cytoskeleton; polarization; viral proteins

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