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Int J Hepatol. 2011;2011:438184. doi: 10.4061/2011/438184. Epub 2010 Nov 14.

Hepatobiliary disorders in celiac disease: an update.

International journal of hepatology

Kaushal K Prasad, Uma Debi, Saroj K Sinha, Chander K Nain, Kartar Singh

Affiliations

  1. Department of Superspeciality of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India.

PMID: 21994857 PMCID: PMC3170807 DOI: 10.4061/2011/438184

Abstract

This communication reviews recent literature and summarizes hepatobiliary abnormalities that may complicate the clinical course of celiac disease. A wide spectrum of hepatobiliary diseases has been described, including asymptomatic elevations of liver enzyme levels, nonspecific hepatitis, nonalcoholic fatty liver disease, and autoimmune and cholestatic liver disease. Moreover, in the majority of patients, liver enzyme levels will normalize on a gluten-free diet. In addition, celiac disease may be associated with rare hepatic complications, such as hepatic T-cell lymphoma. Because many celiac patients do not have overt gastrointestinal symptoms, a high index of suspicion is required. Simple methods of detecting celiac disease such as serum antibody tests help in the early identification of the disease, thus preventing serious complications of the disorder. The IgG DGP antibody test and IgA tTG antibody test used in combination are an excellent screening test for suspected cases of celiac disease.

References

  1. Eur J Gastroenterol Hepatol. 2009 Sep;21(9):1092-4 - PubMed
  2. Br J Dermatol. 1984 Oct;111(4):395-402 - PubMed
  3. Gastroenterol Clin Biol. 2004 Oct;28(10 Pt 1):903-5 - PubMed
  4. Eur J Gastroenterol Hepatol. 2009 Apr;21(4):452-9 - PubMed
  5. Horm Metab Res. 2010 Jan;42(1):45-9 - PubMed
  6. Gastroenterology. 2005 Apr;128(4 Suppl 1):S79-86 - PubMed
  7. Am Fam Physician. 2006 Jun 1;73(11):1961-8 - PubMed
  8. Clin Gastroenterol Hepatol. 2008 Jul;6(7):803-6 - PubMed
  9. Am J Gastroenterol. 2010 Mar;105(3):691-6 - PubMed
  10. Am J Gastroenterol. 2002 Dec;97(12):3196-8 - PubMed
  11. J Clin Gastroenterol. 2007 Aug;41(7):724-5 - PubMed
  12. Blood. 1994 Sep 1;84(5):1361-92 - PubMed
  13. Indian J Pediatr. 2006 Sep;73(9):809-11 - PubMed
  14. J Clin Lab Anal. 2006;20(5):184-9 - PubMed
  15. Lancet. 1978 Feb 4;1(8058):230-3 - PubMed
  16. Dig Liver Dis. 2003 Jul;35 Suppl 3:S12-6 - PubMed
  17. Am J Gastroenterol. 2006 Oct;101(10):2333-40 - PubMed
  18. Praxis (Bern 1994). 2009 Mar 18;98(6):330-4 - PubMed
  19. J Clin Gastroenterol. 2006 Feb;40(2):135-9 - PubMed
  20. Clin Haematol. 1982 Jun;11(2):411-35 - PubMed
  21. Autoimmun Rev. 2009 Feb;8(4):316-9 - PubMed
  22. Digestion. 2009;80(1):18-24 - PubMed
  23. J Gastroenterol Hepatol. 2006 Jan;21(1 Pt 2):332-4 - PubMed
  24. Gut. 1990 Jan;31(1):111-4 - PubMed
  25. Can J Gastroenterol. 2008 Nov;22(11):909-11 - PubMed
  26. World J Gastroenterol. 2006 Mar 14;12(10):1503-8 - PubMed
  27. Rev Med Interne. 2010 Feb;31(2):160-2 - PubMed
  28. Histopathology. 1977 Nov;1(6):421-30 - PubMed
  29. World J Gastroenterol. 2010 Jul 7;16(25):3144-52 - PubMed
  30. Z Gastroenterol. 2006 May;44(5):395-8 - PubMed
  31. Am J Gastroenterol. 1987 Nov;82(11):1186-9 - PubMed
  32. Gastroenterol Hepatol. 2008 Jan;31(1):8-11 - PubMed
  33. Aliment Pharmacol Ther. 2010 Jan 15;31(2):253-60 - PubMed
  34. J Pediatr Gastroenterol Nutr. 2001 Sep;33(3):329-32 - PubMed
  35. Clin Rev Allergy Immunol. 2009 Feb;36(1):62-70 - PubMed
  36. N Engl J Med. 1991 Dec 12;325(24):1709-19 - PubMed
  37. Am J Gastroenterol. 2002 Oct;97(10):2609-13 - PubMed
  38. Semin Liver Dis. 2002 Feb;22(1):59-72 - PubMed
  39. Dig Liver Dis. 2004 Feb;36(2):157-62 - PubMed
  40. World J Gastroenterol. 2005 Jun 7;11(21):3323-6 - PubMed
  41. Nephrol Dial Transplant. 2009 Aug;24(8):2476-81 - PubMed
  42. Best Pract Res Clin Gastroenterol. 2002 Feb;16(1):37-49 - PubMed
  43. Ann N Y Acad Sci. 2009 Sep;1173:670-4 - PubMed
  44. J Clin Gastroenterol. 1993 Jan;16(1):16-21 - PubMed
  45. Gut. 1994 Sep;35(9):1226-32 - PubMed
  46. Gastroenterol Clin Biol. 2010 Jan;34(1):40-2 - PubMed
  47. J Gastroenterol Hepatol. 2002 Jan;17(1):6-16 - PubMed
  48. Gut. 2004 Jul;53(7):1032-4 - PubMed
  49. Eur J Gastroenterol Hepatol. 2009 May;21(5):576-9 - PubMed
  50. Gastroenterology. 2002 Apr;122(4):881-8 - PubMed
  51. Liver Int. 2008 Apr;28(4):467-76 - PubMed
  52. J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e348-52 - PubMed
  53. Isr J Med Sci. 1995 Apr;31(4):218-20 - PubMed
  54. Rev Esp Enferm Dig. 2007 Nov;99(11):648-52 - PubMed
  55. Dig Liver Dis. 2002 Apr;34(4):258-61 - PubMed
  56. Hepatogastroenterology. 1998 Nov-Dec;45(24):2344-7 - PubMed
  57. J Clin Lab Anal. 2005;19(1):6-10 - PubMed
  58. Haematologica. 2004 Nov;89(11):1299-305 - PubMed
  59. J Med Genet. 1999 Sep;36(9):687-90 - PubMed
  60. Gastroenterol Hepatol. 2010 Jan;33(1):17-20 - PubMed
  61. J Clin Microbiol. 2010 Sep;48(9):3416-8 - PubMed
  62. J Clin Gastroenterol. 2009 Apr;43(4):307-11 - PubMed
  63. Eur J Gastroenterol Hepatol. 2005 Oct;17(10):1015-7 - PubMed
  64. Clin Gastroenterol Hepatol. 2007 Jan;5(1):63-69.e1 - PubMed
  65. J Rheumatol. 2003 Dec;30(12):2613-9 - PubMed
  66. Gastroenterology. 2002 Aug;123(2):444-9 - PubMed
  67. Clin Chim Acta. 2005 Jun;356(1-2):102-9 - PubMed
  68. J Med Case Rep. 2009 Feb 16;3:68 - PubMed
  69. Clin Chim Acta. 2007 Feb;376(1-2):126-35 - PubMed
  70. Blood. 1990 Jun 1;75(11):2213-9 - PubMed
  71. Hepatology. 2009 Jun;49(6):1877-87 - PubMed
  72. Endocr Rev. 2002 Aug;23(4):464-83 - PubMed
  73. Nephrol Dial Transplant. 2009 Nov;24(11):3545-8 - PubMed
  74. Eur J Gastroenterol Hepatol. 2001 Jun;13(6):635-7 - PubMed
  75. Ann Intern Med. 1988 Nov 1;109(9):713-7 - PubMed
  76. Hepatology. 2007 Nov;46(5):1650-8 - PubMed
  77. Dig Liver Dis. 2004 May;36(5):333-6 - PubMed
  78. Gastroenterol Hepatol. 2008 Jan;31(1):25-8 - PubMed
  79. J Clin Gastroenterol. 1997 Jul;25(1):328-9 - PubMed
  80. Dig Liver Dis. 2010 Sep;42(9):620-3 - PubMed
  81. World J Pediatr. 2010 Feb;6(1):60-4 - PubMed
  82. Med Hypotheses. 2006;66(4):769-72 - PubMed
  83. Clin Chem. 2007 Dec;53(12):2186-92 - PubMed
  84. Dig Dis Sci. 1998 Oct;43(10):2190-5 - PubMed
  85. Gastroenterol Hepatol. 2004 Aug-Sep;27(7):408-10 - PubMed

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