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López MA, Stashenko EE, Fuentes JL. Chemical composition and antigenotoxic properties of Lippia alba essential oils. Genet Mol Biol. 2011;34(3):479-88doi: 10.1590/S1415-47572011005000030.
López, M. A., Stashenko, E. E., & Fuentes, J. L. (2011). Chemical composition and antigenotoxic properties of Lippia alba essential oils. Genetics and molecular biology, 34(3), 479-88. https://doi.org/10.1590/S1415-47572011005000030
López, Molkary Andrea, et al. "Chemical composition and antigenotoxic properties of Lippia alba essential oils." Genetics and molecular biology vol. 34,3 (2011): 479-88. doi: https://doi.org/10.1590/S1415-47572011005000030
López MA, Stashenko EE, Fuentes JL. Chemical composition and antigenotoxic properties of Lippia alba essential oils. Genet Mol Biol. 2011 Jul;34(3):479-88. doi: 10.1590/S1415-47572011005000030. Epub 2011 Jul 01. PMID: 21931523; PMCID: PMC3168191.
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Genet Mol Biol. 2011 Jul;34(3):479-88. doi: 10.1590/S1415-47572011005000030. Epub 2011 Jul 01.

Chemical composition and antigenotoxic properties of Lippia alba essential oils.

Genetics and molecular biology

Molkary Andrea López, Elena E Stashenko, Jorge Luis Fuentes

Affiliations

  1. Microbiology and Environmental Mutagenesis Laboratory, Biology School, Faculty of Sciences, Industrial University of Santander, Bucaramanga, Colombia.

PMID: 21931523 PMCID: PMC3168191 DOI: 10.1590/S1415-47572011005000030

Abstract

The present work evaluated the chemical composition and the DNA protective effect of the essential oils (EOs) from Lippia alba against bleomycin-induced genotoxicity. EO constituents were determined by Gas Chromatography/Mass Spectrometric (GC-MS) analysis. The major compounds encountered being citral (33% geranial and 25% neral), geraniol (7%) and trans-β-caryophyllene (7%) for L. alba specimen COL512077, and carvone (38%), limonene (33%) and bicyclosesquiphellandrene (8%) for the other, COL512078. The genotoxicity and antigenotoxicity of EO and the compounds citral, carvone and limonene, were assayed using the SOS Chromotest in Escherichia coli. The EOs were not genotoxic in the SOS chromotest, but one of the major compound (limonene) showed genotoxicity at doses between 97 and 1549 mM. Both EOs protected bacterial cells against bleomycin-induced genotoxicity. Antigenotoxicity in the two L. alba chemotypes was related to the major compounds, citral and carvone, respectively. The results were discussed in relation to the chemopreventive potential of L. alba EOs and its major compounds.

Keywords: Lippia alba; SOS chromotest; antigenotoxicity; bleomycin; essential oil

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