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Kakkar A, Wasan SK, Farraye FA. Targeting mucosal healing in Crohn's disease. Gastroenterol Hepatol (N Y). 2011;7(6):374-80
Kakkar, A., Wasan, S. K., & Farraye, F. A. (2011). Targeting mucosal healing in Crohn's disease. Gastroenterology & hepatology, 7(6), 374-80.
Kakkar, Aarti, et al. "Targeting mucosal healing in Crohn's disease." Gastroenterology & hepatology vol. 7,6 (2011): 374-80.
Kakkar A, Wasan SK, Farraye FA. Targeting mucosal healing in Crohn's disease. Gastroenterol Hepatol (N Y). 2011 Jun;7(6):374-80. PMID: 21869869; PMCID: PMC3151410.
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Gastroenterol Hepatol (N Y). 2011 Jun;7(6):374-80.

Targeting mucosal healing in Crohn's disease.

Gastroenterology & hepatology

Aarti Kakkar, Sharmeel K Wasan, Francis A Farraye

Affiliations

  1. Dr. Kakkar is a Fellow in Gastroenterology, Dr. Wasan is a Clinical Instructor of Medicine, and Dr. Farraye is a Professor of Medicine and Clinical Director of the Section of Gastroenterology at Boston University School of Medicine in Boston, Massachusetts. Drs. Kakkar, Wasan, and Farraye are also affiliated with the Section of Gastroenterology at Boston Medical Center in Boston, Massachusetts.

PMID: 21869869 PMCID: PMC3151410

Abstract

The goal of medical treatment for Crohn's disease includes improving patients' quality of life while reducing the need for hospitalization and surgery. The current medical armamentarium includes 5-aminosalicylates, corticosteroids, immunomodulators, and biologic agents. In the past, response to treatment was measured by clinical improvement in symptoms; however, with the advent of disease-modifying medications, mucosal healing has emerged as an increasingly important goal of therapy. Mucosal healing, or endoscopic remission, is associated with increased rates of clinical remission, fewer hospitalizations, and fewer abdominal surgeries. Both the immunomodulator and biologic classes of medications are effective at inducing mucosal healing. Despite several limitations, mucosal healing has become a desirable and valid measure of disease activity.

Keywords: Crohn's disease; biologic agents; deep remission; endoscopic remission; immunomodulators; mucosal healing

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