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Tao Z, Zhao Z, Lee CC. 5'- Adenosine monophosphate induced hypothermia reduces early stage myocardial ischemia/reperfusion injury in a mouse model. Am J Transl Res. 2011;3(4):351-61
Tao, Z., Zhao, Z., & Lee, C. C. (2011). 5'- Adenosine monophosphate induced hypothermia reduces early stage myocardial ischemia/reperfusion injury in a mouse model. American journal of translational research, 3(4), 351-61.
Tao, Zhenyin, et al. "5'- Adenosine monophosphate induced hypothermia reduces early stage myocardial ischemia/reperfusion injury in a mouse model." American journal of translational research vol. 3,4 (2011): 351-61.
Tao Z, Zhao Z, Lee CC. 5'- Adenosine monophosphate induced hypothermia reduces early stage myocardial ischemia/reperfusion injury in a mouse model. Am J Transl Res. 2011 Aug 15;3(4):351-61. Epub 2011 Jul 18. PMID: 21904655; PMCID: PMC3158737.
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Am J Transl Res. 2011 Aug 15;3(4):351-61. Epub 2011 Jul 18.

5'- Adenosine monophosphate induced hypothermia reduces early stage myocardial ischemia/reperfusion injury in a mouse model.

American journal of translational research

Zhenyin Tao, Zhaoyang Zhao, Cheng Chi Lee

Affiliations

  1. Department of Biochemistry and Molecular Biology, Medical School of The University of Texas Health Science Center at Houston Houston TX 77225, USA.

PMID: 21904655 PMCID: PMC3158737

Abstract

Early intervention using hypothermia treatment has been shown to reduce early inflammation, apoptosis and infarct size in animal models of cardiac ischemia/reperfusion. We have shown that 5'-adenosine monophosphate (5'-AMP) can induce a reversible deep hypothermia in mammals. We hypothesize that 5'-AMP-induced hypothermia (AIH) may reduce ischemic/reperfusion damage following myocardial infarct. C57BL/6J male mice were subjected to myocardial ischemia by ligating the left anterior descending coronary artery (LAD) followed by reperfusion. Compared to euthermic controls, mice given AIH treatment exhibited significant inhibition of neutrophil infiltration and a reduction in matrix metallopeptidase 9 (MMP-9) expressions in the infarcted myocardium. A decrease in terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive nuclei in the left ventricle myocardium were also observed. The overall infarct size of the heart was significantly smaller in AIH treated mice. Myocardial ischemia in mice given 5'-AMP without hypothermia had similar ischemia/reperfusion injuries as the euthermic control. Thus, the AIH cardio-protective effects were primarily hypothermia based.

Keywords: 5'-adenosine monophosphate; Hypothermia; inflammation; ischemia/reperfusion injury; myocardial infarct

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