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Germann S, Gratadou L, Dutertre M, et al. Splicing programs and cancer. J Nucleic Acids. 2011;2012:269570doi: 10.1155/2012/269570.
Germann, S., Gratadou, L., Dutertre, M., & Auboeuf, D. (2012). Splicing programs and cancer. Journal of nucleic acids, 2012269570. https://doi.org/10.1155/2012/269570
Germann, Sophie, et al. "Splicing programs and cancer." Journal of nucleic acids vol. 2012 (2012): 269570. doi: https://doi.org/10.1155/2012/269570
Germann S, Gratadou L, Dutertre M, Auboeuf D. Splicing programs and cancer. J Nucleic Acids. 2012;2012:269570. doi: 10.1155/2012/269570. Epub 2011 Oct 24. PMID: 22132318; PMCID: PMC3202119.
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J Nucleic Acids. 2012;2012:269570. doi: 10.1155/2012/269570. Epub 2011 Oct 24.

Splicing programs and cancer.

Journal of nucleic acids

Sophie Germann, Lise Gratadou, Martin Dutertre, Didier Auboeuf

Affiliations

  1. Université de Lyon, 28 rue Laënnec, 69008 Lyon, France.

PMID: 22132318 PMCID: PMC3202119 DOI: 10.1155/2012/269570

Abstract

Numerous studies report splicing alterations in a multitude of cancers by using gene-by-gene analysis. However, understanding of the role of alternative splicing in cancer is now reaching a new level, thanks to the use of novel technologies allowing the analysis of splicing at a large-scale level. Genome-wide analyses of alternative splicing indicate that splicing alterations can affect the products of gene networks involved in key cellular programs. In addition, many splicing variants identified as being misregulated in cancer are expressed in normal tissues. These observations suggest that splicing programs contribute to specific cellular programs that are altered during cancer initiation and progression. Supporting this model, recent studies have identified splicing factors controlling cancer-associated splicing programs. The characterization of splicing programs and their regulation by splicing factors will allow a better understanding of the genetic mechanisms involved in cancer initiation and progression and the development of new therapeutic targets.

References

  1. Cancer Sci. 2011 Feb;102(2):309-16 - PubMed
  2. Nature. 2002 Dec 12;420(6916):691-5 - PubMed
  3. Neuron. 2009 May 28;62(4):494-509 - PubMed
  4. Nat Struct Mol Biol. 2009 Feb;16(2):130-7 - PubMed
  5. Lancet Oncol. 2009 Apr;10(4):381-90 - PubMed
  6. Oncogene. 2007 Jun 28;26(30):4372-82 - PubMed
  7. Endocr Relat Cancer. 2011 Jul 01;18(4):R91-R102 - PubMed
  8. Cancer Res. 2011 Mar 15;71(6):2045-55 - PubMed
  9. Genes Dev. 2008 Sep 15;22(18):2550-63 - PubMed
  10. Int J Biochem Cell Biol. 2007;39(7-8):1432-49 - PubMed
  11. Cell. 2010 Aug 20;142(4):625-36 - PubMed
  12. Nat Genet. 2008 Dec;40(12):1413-5 - PubMed
  13. Nucleic Acids Res. 2010 May;38(9):2825-38 - PubMed
  14. Cell Death Differ. 2008 Dec;15(12):1815-23 - PubMed
  15. Cell. 2011 Mar 4;144(5):646-74 - PubMed
  16. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1894-9 - PubMed
  17. Nat Struct Mol Biol. 2007 Mar;14(3):185-93 - PubMed
  18. Nat Biotechnol. 2010 May;28(5):511-5 - PubMed
  19. BMC Genomics. 2010 Nov 30;11:676 - PubMed
  20. Lancet Oncol. 2007 Apr;8(4):349-57 - PubMed
  21. J Biol Chem. 2005 Nov 18;280(46):38639-47 - PubMed
  22. Cell. 2006 Jul 14;126(1):37-47 - PubMed
  23. Nature. 2008 Mar 13;452(7184):230-3 - PubMed
  24. Biochem Soc Trans. 2008 Jun;36(Pt 3):505-7 - PubMed
  25. J Cell Sci. 2008 Oct 15;121(Pt 20):3487-95 - PubMed
  26. Science. 2010 Jul 23;329(5990):439-43 - PubMed
  27. EMBO J. 2011 Feb 2;30(3):510-23 - PubMed
  28. Nat Rev Urol. 2009 Aug;6(8):454-60 - PubMed
  29. J Thorac Oncol. 2009 Jun;4(6):674-8 - PubMed
  30. Nucleic Acids Res. 2008 Nov;36(20):6535-47 - PubMed
  31. Genome Med. 2011 May 27;3(5):32 - PubMed
  32. Mol Cell Biol. 2011 Jan;31(1):138-50 - PubMed
  33. Biochim Biophys Acta. 2009 Jan;1792(1):14-26 - PubMed
  34. Cancer Res. 2010 Feb 1;70(3):896-905 - PubMed
  35. Cancer Res. 2002 Jul 15;62(14):4123-31 - PubMed
  36. Oncogene. 2010 Sep 30;29(39):5392-403 - PubMed
  37. RNA Biol. 2010 Jul-Aug;7(4):495-503 - PubMed
  38. Int J Biochem Cell Biol. 2011 Jul;43(7):969-80 - PubMed
  39. RNA Biol. 2009 Nov-Dec;6(5):546-62 - PubMed
  40. PLoS One. 2010 Aug 06;5(8):e11981 - PubMed
  41. Nat Struct Mol Biol. 2010 Sep;17(9):1114-23 - PubMed
  42. Brain. 2009 Aug;132(Pt 8):2277-88 - PubMed
  43. Am J Pathol. 2009 Aug;175(2):461-72 - PubMed
  44. J Cell Biol. 2010 Oct 4;191(1):87-99 - PubMed
  45. BMC Genomics. 2010 Jan 04;11:5 - PubMed
  46. Oncogene. 2007 Jul 26;26(34):4961-8 - PubMed
  47. Cancer Res. 2007 Jun 15;67(12):5635-42 - PubMed
  48. Nature. 2008 Nov 27;456(7221):470-6 - PubMed
  49. Mol Cell. 2009 Mar 13;33(5):591-601 - PubMed
  50. Cancer Res. 2010 Jan 1;70(1):229-39 - PubMed
  51. J Biol Chem. 2008 Jan 18;283(3):1211-5 - PubMed
  52. Mol Cell. 2005 Dec 22;20(6):881-90 - PubMed
  53. Cell. 2004 Aug 6;118(3):277-9 - PubMed
  54. Nat Struct Mol Biol. 2011 Jun;18(6):673-9 - PubMed
  55. Genes Dev. 2005 Nov 15;19(22):2705-14 - PubMed
  56. Mol Cell. 2009 Dec 25;36(6):996-1006 - PubMed
  57. Nat Genet. 2008 Dec;40(12):1416-25 - PubMed
  58. Nature. 2010 Jan 21;463(7279):364-8 - PubMed
  59. RNA Biol. 2010 Jul-Aug;7(4):403-11 - PubMed
  60. Cell. 2009 Feb 20;136(4):701-18 - PubMed
  61. Curr Genomics. 2008 Dec;9(8):556-70 - PubMed
  62. Mol Cancer Res. 2010 Jul;8(7):961-74 - PubMed
  63. Cancer Res. 2003 Oct 1;63(19):6154-7 - PubMed
  64. Front Biosci. 2008 Jan 01;13:1090-105 - PubMed
  65. J Pathol. 2010 Jan;220(2):152-63 - PubMed
  66. J Biol Chem. 2000 Dec 22;275(51):40195-201 - PubMed
  67. J Cell Sci. 2006 Jul 1;119(Pt 13):2635-41 - PubMed
  68. BMC Genomics. 2010 Jun 03;11:352 - PubMed
  69. BMC Cell Biol. 2004 Jan 22;5:5 - PubMed
  70. Genes Dev. 2010 Nov 1;24(21):2343-64 - PubMed
  71. J Cell Biol. 2007 Mar 26;176(7):929-39 - PubMed
  72. PLoS One. 2010 Oct 27;5(10):e13690 - PubMed
  73. RNA. 2008 May;14(5):802-13 - PubMed
  74. BMC Genomics. 2008 May 12;9:216 - PubMed
  75. Oncogene. 2004 May 6;23(21):3781-9 - PubMed
  76. Dis Model Mech. 2008 Jul-Aug;1(1):37-42 - PubMed
  77. Cell. 2000 Jan 7;100(1):57-70 - PubMed
  78. Proteomics. 2011 Jun;11(11):2275-82 - PubMed
  79. Genes Dev. 2007 Jul 1;21(13):1636-52 - PubMed
  80. EMBO Rep. 2009 Sep;10(9):1029-35 - PubMed
  81. Bioessays. 2006 Apr;28(4):378-86 - PubMed
  82. BMB Rep. 2009 Mar 31;42(3):125-30 - PubMed
  83. Am J Pathol. 2004 Apr;164(4):1243-51 - PubMed
  84. Nat Struct Mol Biol. 2009 Jun;16(6):670-6 - PubMed
  85. Mol Gen Genet. 1998 Nov;260(2-3):232-41 - PubMed
  86. BMC Genomics. 2006 Dec 27;7:325 - PubMed
  87. Genome Biol. 2007;8(4):R64 - PubMed
  88. BMC Med Genomics. 2011 Apr 18;4:35 - PubMed
  89. Nat Genet. 2005 Aug;37(8):844-52 - PubMed
  90. PLoS One. 2011 Apr 29;6(4):e19420 - PubMed
  91. Nature. 2010 May 6;465(7294):53-9 - PubMed
  92. EMBO Rep. 2008 Nov;9(11):1087-93 - PubMed
  93. Nat Genet. 2008 Feb;40(2):225-31 - PubMed
  94. Mol Cell. 2005 Jul 1;19(1):1-13 - PubMed
  95. Mol Cell Proteomics. 2008 Jul;7(7):1214-24 - PubMed
  96. EMBO J. 2010 Oct 6;29(19):3286-300 - PubMed
  97. Nat Methods. 2009 May;6(5):377-82 - PubMed
  98. FEBS J. 2010 Feb;277(4):856-66 - PubMed
  99. Nucleic Acids Res. 2010 Nov;38(21):7651-64 - PubMed

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