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Weller RE, Stoeckel LE, Milby JB, et al. Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report. Open Neuroimag J. 2011;5:57-64doi: 10.2174/1874440001105010057.
Weller, R. E., Stoeckel, L. E., Milby, J. B., Bolding, M., Twieg, D. B., Knowlton, R. C., Avison, M. J., & Ding, Z. (2011). Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report. The open neuroimaging journal, 557-64. https://doi.org/10.2174/1874440001105010057
Weller, Rosalyn E, et al. "Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report." The open neuroimaging journal vol. 5 (2011): 57-64. doi: https://doi.org/10.2174/1874440001105010057
Weller RE, Stoeckel LE, Milby JB, Bolding M, Twieg DB, Knowlton RC, Avison MJ, Ding Z. Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report. Open Neuroimag J. 2011;5:57-64. doi: 10.2174/1874440001105010057. Epub 2011 Oct 28. PMID: 22135719; PMCID: PMC3227861.
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Open Neuroimag J. 2011;5:57-64. doi: 10.2174/1874440001105010057. Epub 2011 Oct 28.

Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report.

The open neuroimaging journal

Rosalyn E Weller, Luke E Stoeckel, Jesse B Milby, Mark Bolding, Donald B Twieg, Robert C Knowlton, Malcolm J Avison, Zhaohua Ding

Affiliations

  1. Department of Psychology, University of Alabama at Birmingham (UAB), Birmingham, AL, London.

PMID: 22135719 PMCID: PMC3227861 DOI: 10.2174/1874440001105010057

Abstract

Models of addiction include abnormalities in parts of the brain involving executive function/inhibitory control. Although previous studies have reported evidence of structural abnormalities in cocaine-dependent individuals, none have specifically targeted the homeless. The present preliminary study investigated brain structure in such an understudied group, homeless, crack-cocaine-dependent African American men (n = 9), comparing it to that in healthy controls (n = 8). Structural data were analyzed using voxel based morphometry (VBM) and a regions of interest (ROI) analysis. Homeless cocaine-dependent individuals had smaller gray matter volume in dorsolateral prefrontal cortex, anterior cingulate, the cerebellum, insula, and superior temporal gyrus. Most of these areas subserve executive function or inhibitory control. These results are similar to those found in most previous studies of non-homeless cocaine-dependent individuals. Reduced gray matter in executive function/inhibitory control regions of the brain in cocaine-dependent individuals may be a preexisting risk factor for the development of addiction and/or a consequence of drug abuse.

Keywords: Addiction; VBM; executive function; inhibitory control.

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