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Lu A, Smart TP, Epps TH, et al. L-Proline Functionalized Polymers Prepared by RAFT Polymerization and Their Assemblies as Supported Organocatalysts. Macromolecules. 2011;44(18):7233-7241doi: 10.1021/ma201256m.
Lu, A., Smart, T. P., Epps, T. H., Longbottom, D. A., & O'Reilly, R. K. (2011). L-Proline Functionalized Polymers Prepared by RAFT Polymerization and Their Assemblies as Supported Organocatalysts. Macromolecules, 44(18), 7233-7241. https://doi.org/10.1021/ma201256m
Lu, Annhelen, et al. "L-Proline Functionalized Polymers Prepared by RAFT Polymerization and Their Assemblies as Supported Organocatalysts." Macromolecules vol. 44,18 (2011): 7233-7241. doi: https://doi.org/10.1021/ma201256m
Lu A, Smart TP, Epps TH, Longbottom DA, O'Reilly RK. L-Proline Functionalized Polymers Prepared by RAFT Polymerization and Their Assemblies as Supported Organocatalysts. Macromolecules. 2011 Sep 27;44(18):7233-7241. doi: 10.1021/ma201256m. PMID: 22053116; PMCID: PMC3205999.
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Macromolecules. 2011 Sep 27;44(18):7233-7241. doi: 10.1021/ma201256m.

L-Proline Functionalized Polymers Prepared by RAFT Polymerization and Their Assemblies as Supported Organocatalysts.

Macromolecules

Annhelen Lu, Thomas P Smart, Thomas H Epps, Deborah A Longbottom, Rachel K O'Reilly

Affiliations

  1. Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, United Kingdom.

PMID: 22053116 PMCID: PMC3205999 DOI: 10.1021/ma201256m

Abstract

We have prepared a range of well-defined copolymers of styrene and L-proline functionalized styrene (5-11 kDa) using reversible addition-fragmentation chain transfer (RAFT) polymerization techniques and explored their use in supported catalysis. Upon deprotection of the L-proline functionalities, the solution self-assembly of these copolymers was investigated in mixed solvent systems. The resulting assemblies were characterized by dynamic light scattering, transmission electron microscopy (on graphene oxide substrates, along with cryo-TEM and tomography), and scanning electron microscopy. The application of these functional assemblies as supported catalysts for the aldol condensation reaction was explored using cyclohexanone and 4-nitrobenzaldehyde. The rate and selectivity of solution catalysis in our self-assembled system were comparable to those of L-proline, and a significant advantage of our system was that the polymer support could be utilized at lower catalyst loadings with comparable activity and also could be recycled a number of times while maintaining activity and selectivity.

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