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Comijs HC, van Marwijk HW, van der Mast RC, et al. The Netherlands study of depression in older persons (NESDO); a prospective cohort study. BMC Res Notes. 2011;4:524doi: 10.1186/1756-0500-4-524.
Comijs, H. C., van Marwijk, H. W., van der Mast, R. C., Naarding, P., Oude Voshaar, R. C., Beekman, A. T., Boshuisen, M., Dekker, J., Kok, R., de Waal, M. W., Penninx, B. W., Stek, M. L., & Smit, J. H. (2011). The Netherlands study of depression in older persons (NESDO); a prospective cohort study. BMC research notes, 4524. https://doi.org/10.1186/1756-0500-4-524
Comijs, Hannie C, et al. "The Netherlands study of depression in older persons (NESDO); a prospective cohort study." BMC research notes vol. 4 (2011): 524. doi: https://doi.org/10.1186/1756-0500-4-524
Comijs HC, van Marwijk HW, van der Mast RC, Naarding P, Oude Voshaar RC, Beekman AT, Boshuisen M, Dekker J, Kok R, de Waal MW, Penninx BW, Stek ML, Smit JH. The Netherlands study of depression in older persons (NESDO); a prospective cohort study. BMC Res Notes. 2011 Dec 05;4:524. doi: 10.1186/1756-0500-4-524. PMID: 22142532; PMCID: PMC3278450.
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BMC Res Notes. 2011 Dec 05;4:524. doi: 10.1186/1756-0500-4-524.

The Netherlands study of depression in older persons (NESDO); a prospective cohort study.

BMC research notes

Hannie C Comijs, Harm W van Marwijk, Roos C van der Mast, Paul Naarding, Richard C Oude Voshaar, Aartjan Tf Beekman, Marjolein Boshuisen, Janny Dekker, Rob Kok, Margot Wm de Waal, Brenda Wjh Penninx, Max L Stek, Johannes H Smit

Affiliations

  1. Department Psychiatry/EMGO Institute for Health and Care Research, VU University Medical Center/GGZinGeest, Amsterdam, The Netherlands. [email protected].

PMID: 22142532 PMCID: PMC3278450 DOI: 10.1186/1756-0500-4-524

Abstract

BACKGROUND: To study late-life depression and its unfavourable course and co morbidities in The Netherlands.

METHODS: We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood.

RESULTS: From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons (≥ 60 years) at 5 locations throughout the Netherlands. Depressed persons were recruited from both mental health care institutes and general practices in order to include persons with late-life depression in various developmental and severity stages. Non-depressed persons were recruited from general practices. The baseline assessment included written questionnaires, interviews, a medical examination, cognitive tests and collection of blood and saliva samples. Information was gathered about mental health outcomes and demographic, psychosocial, biological, cognitive and genetic determinants. The baseline NESDO sample consists of 378 depressed (according to DSM-IV criteria) and 132 non-depressed persons aged 60 through 93 years. 95% had a major depression and 26.5% had dysthymia. Mean age of onset of the depressive disorder was around 49 year. For 33.1% of the depressed persons it was their first episode. 41.0% of the depressed persons had a co morbid anxiety disorder. Follow up assessments are currently going on with 6 monthly written questionnaires and face-to-face interviews after 2 and 6 years.

CONCLUSIONS: The NESDO sample offers the opportunity to study the neurobiological, psychosocial and physical determinants of depression and its long-term course in older persons. Since largely similar measures were used as in the Netherlands Study of Depression and Anxiety (NESDA; age range 18-65 years), data can be pooled thus creating a large longitudinal database of clinically depressed persons with adequate power and a large set of neurobiological, psychosocial and physical variables from both younger and older depressed persons.

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