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Törmä H. Regulation of keratin expression by retinoids. Dermatoendocrinol. 2011;3(3):136-40doi: 10.4161/derm.3.3.15026.
Törmä, H. (2011). Regulation of keratin expression by retinoids. Dermato-endocrinology, 3(3), 136-40. https://doi.org/10.4161/derm.3.3.15026
Törmä, Hans. "Regulation of keratin expression by retinoids." Dermato-endocrinology vol. 3,3 (2011): 136-40. doi: https://doi.org/10.4161/derm.3.3.15026
Törmä H. Regulation of keratin expression by retinoids. Dermatoendocrinol. 2011 Jul;3(3):136-40. doi: 10.4161/derm.3.3.15026. Epub 2011 Jul 01. PMID: 22110773; PMCID: PMC3219164.
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Dermatoendocrinol. 2011 Jul;3(3):136-40. doi: 10.4161/derm.3.3.15026. Epub 2011 Jul 01.

Regulation of keratin expression by retinoids.

Dermato-endocrinology

Hans Törmä

Affiliations

  1. Department of Medical Sciences/Dermatology; Uppsala University; Uppsala, Sweden.

PMID: 22110773 PMCID: PMC3219164 DOI: 10.4161/derm.3.3.15026

Abstract

Vitamin A and its natural and synthetic metabolites (retinoids) affect growth and differentiation of human skin and among the genes affected by retinoids in epidermis are keratin genes. Keratins are intermediate filament proteins that have essential functions in maintaining the structural integrity of epidermis and its appendages. Their expressions are under strict control to produce keratins that are optimally adapted to their environment. In this article, retinoid regulation of keratin expression in cultured human epidermal keratinocytes and in human skin in vivo will be reviewed. The direct and indirect mechanisms involved will be discussed and novel therapeutic strategies will be proposed for utilizing retinoids in skin disorders due to keratin mutations (e.g., epidermolysis bullosa simplex and epidermolytic ichthyosis).

Keywords: epidermis; keratin; keratin mutations; keratinocytes; retinoic acid; retinoids

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