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Martinez-Lavin M. Fibromyalgia: When Distress Becomes (Un)sympathetic Pain. Pain Res Treat. 2011;2012:981565doi: 10.1155/2012/981565.
Martinez-Lavin, M. (2012). Fibromyalgia: When Distress Becomes (Un)sympathetic Pain. Pain research and treatment, 2012981565. https://doi.org/10.1155/2012/981565
Martinez-Lavin, Manuel. "Fibromyalgia: When Distress Becomes (Un)sympathetic Pain." Pain research and treatment vol. 2012 (2012): 981565. doi: https://doi.org/10.1155/2012/981565
Martinez-Lavin M. Fibromyalgia: When Distress Becomes (Un)sympathetic Pain. Pain Res Treat. 2012;2012:981565. doi: 10.1155/2012/981565. Epub 2011 Sep 19. PMID: 22110948; PMCID: PMC3200207.
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Pain Res Treat. 2012;2012:981565. doi: 10.1155/2012/981565. Epub 2011 Sep 19.

Fibromyalgia: When Distress Becomes (Un)sympathetic Pain.

Pain research and treatment

Manuel Martinez-Lavin

Affiliations

  1. Rheumatology Department, National Institute of Cardiology, Juan Badiano 1, 14080 Mexico City, DF, Mexico.

PMID: 22110948 PMCID: PMC3200207 DOI: 10.1155/2012/981565

Abstract

Fibromyalgia is a painful stress-related disorder. A key issue in fibromyalgia research is to investigate how distress could be converted into pain. The sympathetic nervous system is the main element of the stress response system. In animal models, physical trauma, infection, or distressing noise can induce abnormal connections between the sympathetic nervous system and the nociceptive system. Dorsal root ganglia sodium channels facilitate this type of sympathetic pain. Similar mechanisms may operate in fibromyalgia. Signs of sympathetic hyperactivity have been described in this condition. Genetic factors and/or distressful lifestyle may lead to this state of sympathetic hyperactivity. Trauma and infection are recognized fibromyalgia triggers. Women who suffer from fibromyalgia have catecholamine-evoked pain. Sympathetic dysfunction may also explain nonpain-related fibromyalgia symptoms. In conclusion, in fibromyalgia, distress could be converted into pain through forced hyperactivity of the sympathetic component of the stress response system.

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