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Mathias CJ, Low DA, Iodice V, et al. Postural tachycardia syndrome--current experience and concepts. Nat Rev Neurol. 2011;8(1):22-34doi: 10.1038/nrneurol.2011.187.
Mathias, C. J., Low, D. A., Iodice, V., Owens, A. P., Kirbis, M., & Grahame, R. (2011). Postural tachycardia syndrome--current experience and concepts. Nature reviews. Neurology, 8(1), 22-34. https://doi.org/10.1038/nrneurol.2011.187
Mathias, Christopher J, et al. "Postural tachycardia syndrome--current experience and concepts." Nature reviews. Neurology vol. 8,1 (2011): 22-34. doi: https://doi.org/10.1038/nrneurol.2011.187
Mathias CJ, Low DA, Iodice V, Owens AP, Kirbis M, Grahame R. Postural tachycardia syndrome--current experience and concepts. Nat Rev Neurol. 2011 Dec 06;8(1):22-34. doi: 10.1038/nrneurol.2011.187. PMID: 22143364.
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Nat Rev Neurol. 2011 Dec 06;8(1):22-34. doi: 10.1038/nrneurol.2011.187.

Postural tachycardia syndrome--current experience and concepts.

Nature reviews. Neurology

Christopher J Mathias, David A Low, Valeria Iodice, Andrew P Owens, Mojca Kirbis, Rodney Grahame

Affiliations

  1. Autonomic and Neurovascular Medicine Unit, Imperial College London, St Mary's Hospital, 2nd Floor, Queen Elizabeth the Queen Mother Wing, Praed Street, London W2 1NY, UK. c.mathias@ imperial.ac.uk

PMID: 22143364 DOI: 10.1038/nrneurol.2011.187

Abstract

Postural tachycardia syndrome (PoTS) is a poorly understood but important cause of orthostatic intolerance resulting from cardiovascular autonomic dysfunction. PoTS is distinct from the syndromes of autonomic failure usually associated with orthostatic hypotension, such as pure autonomic failure and multiple system atrophy. Individuals affected by PoTS are mainly young (aged between 15 years and 40 years) and predominantly female. The symptoms--palpitations, dizziness and occasionally syncope--mainly occur when the patient is standing upright, and are often relieved by sitting or lying flat. Common stimuli in daily life, such as modest exertion, food ingestion and heat, are now recognized to be capable of exacerbating the symptoms. Onset of the syndrome can be linked to infection, trauma, surgery or stress. PoTS can be associated with various other disorders; in particular, joint hypermobility syndrome (also known as Ehlers-Danlos syndrome hypermobility type, formerly termed Ehlers-Danlos syndrome type III). This Review describes the characteristics and neuroepidemiology of PoTS, and outlines possible pathophysiological mechanisms of this syndrome, as well as current and investigational treatments.

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