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Pajaro OE, Jaroszewski DE, Scott RL, et al. Antibody-mediated rejection in heart transplantation: case presentation with a review of current international guidelines. J Transplant. 2011;2011:351950doi: 10.1155/2011/351950.
Pajaro, O. E., Jaroszewski, D. E., Scott, R. L., Kalya, A. V., Tazelaar, H. D., & Arabia, F. A. (2011). Antibody-mediated rejection in heart transplantation: case presentation with a review of current international guidelines. Journal of transplantation, 2011351950. https://doi.org/10.1155/2011/351950
Pajaro, Octavio E, et al. "Antibody-mediated rejection in heart transplantation: case presentation with a review of current international guidelines." Journal of transplantation vol. 2011 (2011): 351950. doi: https://doi.org/10.1155/2011/351950
Pajaro OE, Jaroszewski DE, Scott RL, Kalya AV, Tazelaar HD, Arabia FA. Antibody-mediated rejection in heart transplantation: case presentation with a review of current international guidelines. J Transplant. 2011;2011:351950. doi: 10.1155/2011/351950. Epub 2011 Dec 06. PMID: 22174983; PMCID: PMC3235906.
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J Transplant. 2011;2011:351950. doi: 10.1155/2011/351950. Epub 2011 Dec 06.

Antibody-mediated rejection in heart transplantation: case presentation with a review of current international guidelines.

Journal of transplantation

Octavio E Pajaro, Dawn E Jaroszewski, Robert L Scott, Anantharam V Kalya, Henry D Tazelaar, Francisco A Arabia

Affiliations

  1. Department of Surgery, Division of Cardiothoracic Surgery, Mayo Clinic Arizona, 5777 E. Mayo Boulevard, Phoenix, AZ 85054, USA.

PMID: 22174983 PMCID: PMC3235906 DOI: 10.1155/2011/351950

Abstract

Antibody-mediated rejection (AMR) (humoral rejection) of cardiac allografts remains difficult to diagnose and treat. Interest in AMR of cardiac allografts has increased over the last decade as it has become apparent that untreated humoral rejection threatens graft and patient survival. An international and multidisciplinary consensus group has formulated guidelines for the diagnosis and treatment of AMR and established that identification of circulating or donor-specific antibodies is not required and that asymptomatic AMR, that is, biopsy-proven AMR without cardiac dysfunction is a real entity with worsened prognosis. Strict criteria for the diagnosis of cardiac AMR have not been firmly established, although the diagnosis relies heavily on tissue pathological findings. Therapy remains largely empirical. We review an unfortunate experience with one of our patients and summarize recommended criteria for the diagnosis of AMR and potential treatment schemes with a focus on current limitations and the need for future research and innovation.

References

  1. J Heart Lung Transplant. 2000 Jun;19(6):518-21 - PubMed
  2. J Heart Lung Transplant. 2010 Jun;29(6):599-602 - PubMed
  3. Am J Transplant. 2005 Nov;5(11):2778-85 - PubMed
  4. Lancet. 2009 Feb 28;373(9665):759-67 - PubMed
  5. J Heart Lung Transplant. 2011 Feb;30(2):136-8 - PubMed
  6. J Heart Lung Transplant. 2005 May;24(5):628-30 - PubMed
  7. Curr Opin Organ Transplant. 2010 Feb;15(1):42-8 - PubMed
  8. J Heart Lung Transplant. 2011 Feb;30(2):144-50 - PubMed
  9. Am J Transplant. 2006 Jun;6(6):1377-86 - PubMed
  10. Am J Transplant. 2006 Jan;6(1):150-60 - PubMed
  11. Nat Rev Drug Discov. 2007 Jul;6(7):515-6 - PubMed
  12. N Engl J Med. 2010 May 20;362(20):1890-900 - PubMed
  13. Transplantation. 2008 Dec 27;86(12):1754-61 - PubMed
  14. Transplantation. 1998 Sep 27;66(6):800-5 - PubMed
  15. Am J Transplant. 2009 Oct;9(10):2312-23 - PubMed
  16. J Heart Lung Transplant. 2009 May;28(5):417-22 - PubMed
  17. Transplantation. 2004 May 15;77(9):1399-405 - PubMed
  18. J Heart Lung Transplant. 2010 May;29(5):504-8 - PubMed
  19. Transplant Proc. 2009 Jan-Feb;41(1):105-7 - PubMed
  20. J Heart Lung Transplant. 2011 Mar;30(3):252-69 - PubMed
  21. J Heart Lung Transplant. 2007 May;26(5):511-5 - PubMed
  22. Int J Radiat Oncol Biol Phys. 1995 Aug 30;33(1):83-8 - PubMed
  23. J Heart Lung Transplant. 2010 Apr;29(4):389-94 - PubMed
  24. J Heart Lung Transplant. 2009 Aug;28(8):781-4 - PubMed
  25. Transplantation. 2003 May 15;75(9):1490-5 - PubMed
  26. J Heart Lung Transplant. 2005 Jul;24(7 Suppl):S219-26 - PubMed
  27. Hum Immunol. 2005 Apr;66(4):350-8 - PubMed
  28. J Heart Lung Transplant. 2005 Sep;24(9):1337-42 - PubMed
  29. J Heart Lung Transplant. 2006 Dec;25(12):1389-95 - PubMed
  30. J Heart Lung Transplant. 2006 Mar;25(3):283-8 - PubMed
  31. J Heart Lung Transplant. 2005 Nov;24(11):1710-20 - PubMed
  32. J Heart Lung Transplant. 1999 Jul;18(7):701-6 - PubMed
  33. J Heart Lung Transplant. 2006 Nov;25(11):1277-82 - PubMed

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