Indian J Pharmacol. 2011 Nov;43(6):652-5. doi: 10.4103/0253-7613.89820.
Protective effect of lisinopril on hepatic ischemia/reperfusion injury in rats.
Indian journal of pharmacology
M A Morsy
Affiliations
Affiliations
- Department of Pharmacology, Faculty of Medicine, El-Minia University, El-Minia, Egypt.
PMID: 22144768
PMCID: PMC3229779 DOI: 10.4103/0253-7613.89820
Abstract
OBJECTIVE: Ischemia/reperfusion (I/R) injury plays a key role in the pathogenesis of hepatic failure in several clinical settings such as liver resection or transplantation. Lisinopril, a widely prescribed drug for various cardiovascular conditions, has been reported to have diverse pharmacological properties. The aim of this study, therefore, was to evaluate a potential protective effect of lisinopril on hepatic I/R injury in rats.
MATERIALS AND METHODS: In anesthetized rats, partial hepatic ischemia was applied for one hour followed by two hours reperfusion. Biochemical analysis of serum and hepatic tissue was done. Hepatic tissue was also subjected to electron microscopy.
RESULTS: Pre-ischemic treatment with lisinopril (10 mg/kg) exerted protection against I/R-induced hepatocellular injury as evident by significant decrease in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin levels, along with hepatic lipid peroxidation, expressed as malondialdehyde content, with a concurrent increase in hepatic nitric oxide content as compared to I/R group. The electron microscopic examination indicated that lisinopril can effectively protect against hepatic I/R injury.
CONCLUSION: Lisinopril provides a protection against hepatic I/R injury in rats. The protective effect is associated with reduction of oxidative stress-induced lipid peroxidation level and enhancement of nitric oxide availability.
Keywords: Ischemia/reperfusion; lisinopril; liver
References
- Biochem Pharmacol. 2001 Aug 15;62(4):509-16 - PubMed
- Clin Exp Pharmacol Physiol. 2008 Feb;35(2):159-67 - PubMed
- Am J Physiol Gastrointest Liver Physiol. 2003 Jan;284(1):G15-26 - PubMed
- Transplantation. 2008 Jan 27;85(2):264-9 - PubMed
- Hepatobiliary Pancreat Dis Int. 2006 Nov;5(4):574-9 - PubMed
- Am J Health Syst Pharm. 2000 Oct 1;57 Suppl 1:S3-7 - PubMed
- Hepatology. 2004 Jun;39(6):1533-43 - PubMed
- Planta Med. 2009 Oct;75(12):1286-92 - PubMed
- Arch Biochem Biophys. 2009 Apr 15;484(2):232-7 - PubMed
- Eur J Clin Invest. 2008 Nov;38(11):820-6 - PubMed
- Transplantation. 2001 Jan 27;71(2):193-8 - PubMed
- Transplantation. 2004 Mar 15;77(5):748-50 - PubMed
- Methods Enzymol. 1978;52:302-10 - PubMed
- Anal Biochem. 2002 Jul 1;306(1):79-82 - PubMed
- Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3057-64 - PubMed
- Eicosanoids. 1992;5 Suppl:S60-2 - PubMed
- J Clin Invest. 1993 Feb;91(2):456-64 - PubMed
- N Engl J Med. 1985 Jan 17;312(3):159-63 - PubMed
- Mediators Inflamm. 2008;2008:305087 - PubMed
- Life Sci. 2006 Jun 6;79(2):121-9 - PubMed
- J Am Coll Surg. 2001 Sep;193(3):264-71 - PubMed
- Clin Transplant. 1997 Feb;11(1):60-5 - PubMed
- J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S212-4 - PubMed
- Mol Cell Biochem. 2009 Jan;320(1-2):149-62 - PubMed
- Am J Physiol. 1993 May;264(5 Pt 2):H1493-7 - PubMed
Publication Types