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Sethi BB, Prakash R, Sharma M, et al. Tricyclic anti-depressant induced mania. Indian J Psychiatry. 1980;22(4):378-83
Sethi, B. B., Prakash, R., Sharma, M., & Sahai, J. (1980). Tricyclic anti-depressant induced mania. Indian journal of psychiatry, 22(4), 378-83.
Sethi, B B, et al. "Tricyclic anti-depressant induced mania." Indian journal of psychiatry vol. 22,4 (1980): 378-83.
Sethi BB, Prakash R, Sharma M, Sahai J. Tricyclic anti-depressant induced mania. Indian J Psychiatry. 1980 Oct;22(4):378-83. PMID: 22058504; PMCID: PMC3013604.
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Indian J Psychiatry. 1980 Oct;22(4):378-83.

Tricyclic anti-depressant induced mania.

Indian journal of psychiatry

B B Sethi, R Prakash, M Sharma, J Sahai

Affiliations

  1. Professor & Head, Department of Psychiatry, K. G.'s Medical College, Lucknow.

PMID: 22058504 PMCID: PMC3013604

Abstract

The authors report four cases of Monopolar Depressed patients who developed manic features for the first time while on tricyclic antidepressant therapy. The phenomenon is viewed as tricyclic antidepressant induced mania. The manic symptoms occurred late in therapy, with moderate doses of tricyclic antidepressants (125-150 mg per day) and were easily controlled with antipsychotic medication. Factors relating to age of patients, metabolic products of tricyclic antidepressants and central nor-adrenergic and dopaminergic systems are considered important and their role has been discussed.

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