Display options
Cite
Hidari KI, Suzuki T. Antiviral agents targeting glycans on dengue virus E-glycoprotein. Expert Rev Anti Infect Ther. 2011;9(11):983-5doi: 10.1586/eri.11.115.
Hidari, K. I., & Suzuki, T. (2011). Antiviral agents targeting glycans on dengue virus E-glycoprotein. Expert review of anti-infective therapy, 9(11), 983-5. https://doi.org/10.1586/eri.11.115
Hidari, Kazuya I P J, and Suzuki, Takashi. "Antiviral agents targeting glycans on dengue virus E-glycoprotein." Expert review of anti-infective therapy vol. 9,11 (2011): 983-5. doi: https://doi.org/10.1586/eri.11.115
Hidari KI, Suzuki T. Antiviral agents targeting glycans on dengue virus E-glycoprotein. Expert Rev Anti Infect Ther. 2011 Nov;9(11):983-5. doi: 10.1586/eri.11.115. PMID: 22029517.
Copy Download .nbib Format: NLM
Share it on

Expert Rev Anti Infect Ther. 2011 Nov;9(11):983-5. doi: 10.1586/eri.11.115.

Antiviral agents targeting glycans on dengue virus E-glycoprotein.

Expert review of anti-infective therapy

Kazuya I P J Hidari, Takashi Suzuki

Affiliations

  1. Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, and Global COE Program for Innovation in Human Health Sciences, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. [email protected]

PMID: 22029517 DOI: 10.1586/eri.11.115

Abstract

The molecular recognition of dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) with arthropod-derived N-glycans on E-glycoprotein is essential for dengue virus (DENV) infection in humans. Therefore, the specific interaction of DC-SIGN with N-glycans on E-glycoprotein is a promising target for development of virus replication inhibitors. This article discusses the findings of a recent report describing antiviral activities of carbohydrate-binding agents, such as lectins and a small molecular weight compound against DENV infection of monocyte-derived dendritic cells. Several plant lectins and the small molecular weight compound Pladimicin-S showed potent inhibition of cellular infection by four DENV serotypes.

Publication Types