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Hashimoto M, Katakura M, Nabika T, et al. Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat - a metabolic syndrome rat model. Med Gas Res. 2011;1(1):26doi: 10.1186/2045-9912-1-26.
Hashimoto, M., Katakura, M., Nabika, T., Tanabe, Y., Hossain, S., Tsuchikura, S., & Shido, O. (2011). Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat - a metabolic syndrome rat model. Medical gas research, 1(1), 26. https://doi.org/10.1186/2045-9912-1-26
Hashimoto, Michio, et al. "Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat - a metabolic syndrome rat model." Medical gas research vol. 1,1 (2011): 26. doi: https://doi.org/10.1186/2045-9912-1-26
Hashimoto M, Katakura M, Nabika T, Tanabe Y, Hossain S, Tsuchikura S, Shido O. Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat - a metabolic syndrome rat model. Med Gas Res. 2011 Nov 03;1(1):26. doi: 10.1186/2045-9912-1-26. PMID: 22146083; PMCID: PMC3231949.
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Med Gas Res. 2011 Nov 03;1(1):26. doi: 10.1186/2045-9912-1-26.

Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat - a metabolic syndrome rat model.

Medical gas research

Michio Hashimoto, Masanori Katakura, Toru Nabika, Yoko Tanabe, Shahdat Hossain, Satoru Tsuchikura, Osamu Shido

Affiliations

  1. Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693-8501, Japan. [email protected].

PMID: 22146083 PMCID: PMC3231949 DOI: 10.1186/2045-9912-1-26

Abstract

BACKGROUND: Hydrogen (H2), a potent free radical scavenger, selectively reduces the hydroxyl radical, which is the most cytotoxic of the reactive oxygen species (ROS). An increase in oxygen free radicals induces oxidative stress, which is known to be involved in the development of metabolic syndrome. Therefore, we investigated whether hydrogen-rich water (HRW) affects metabolic abnormalities in the metabolic syndrome rat model, SHR.Cg-Leprcp/NDmcr (SHR-cp).

METHODS: Male SHR-cp rats (5 weeks old) were divided into 2 groups: an HRW group was given oral HRW for 16 weeks, and a control group was given distilled water. At the end of the experiment, each rat was placed in a metabolic cage for 24 h, fasted for 12 h, and anesthetized; the blood and kidneys were then collected.

RESULTS: Sixteen weeks after HRW administration, the water intake and urine flow measured in the metabolic cages were significantly higher in the HRW group than in the control group. The urinary ratio of albumin to creatinine was significantly lower and creatinine clearance was higher in the HRW group than in the control group. After the 12-h fast, plasma urea nitrogen and creatinine in the HRW group were significantly lower than in the control group. The plasma total antioxidant capacity was significantly higher in the HRW group than in the control group. The glomerulosclerosis score for the HRW group was significantly lower than in the control group, and a significantly positive correlation was observed between this score and plasma urea nitrogen levels.

CONCLUSION: The present findings suggest that HRW conferred significant benefits against abnormalities in the metabolic syndrome model rats, at least by preventing and ameliorating glomerulosclerosis and creatinine clearance.

References

  1. Nephrol Dial Transplant. 2005 Dec;20(12):2661-9 - PubMed
  2. Am J Clin Nutr. 1984 Apr;39(4):612-8 - PubMed
  3. In Vivo. 2005 Sep-Oct;19(5):855-60 - PubMed
  4. J Am Soc Nephrol. 2005 Dec;16(12):3631-41 - PubMed
  5. J Am Soc Nephrol. 2005 Jul;16(7):2134-40 - PubMed
  6. Hypertension. 2003 Dec;42(6):1075-81 - PubMed
  7. Kidney Int. 1987 Feb;31(2):673-89 - PubMed
  8. Neurosci Lett. 2008 Aug 22;441(2):167-72 - PubMed
  9. J Clin Biochem Nutr. 2010 Mar;46(2):140-9 - PubMed
  10. Hypertension. 2001 Apr;37(4):1047-52 - PubMed
  11. Nat Med. 2007 Jun;13(6):688-94 - PubMed
  12. Nutr Res. 2008 Mar;28(3):137-43 - PubMed
  13. Kidney Int. 2007 Dec;72(12):1512-9 - PubMed
  14. Diabetes. 1999 Apr;48(4):927-32 - PubMed
  15. Kidney Int. 2010 Jan;77(2):101-9 - PubMed
  16. Cancer Chemother Pharmacol. 2009 Sep;64(4):753-61 - PubMed
  17. Hypertension. 1994 Dec;24(6):770-8 - PubMed

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