Display options
Cite
Barbara G, Cremon C, Carini G, et al. The immune system in irritable bowel syndrome. J Neurogastroenterol Motil. 2011;17(4):349-59doi: 10.5056/jnm.2011.17.4.349.
Barbara, G., Cremon, C., Carini, G., Bellacosa, L., Zecchi, L., De Giorgio, R., Corinaldesi, R., & Stanghellini, V. (2011). The immune system in irritable bowel syndrome. Journal of neurogastroenterology and motility, 17(4), 349-59. https://doi.org/10.5056/jnm.2011.17.4.349
Barbara, Giovanni, et al. "The immune system in irritable bowel syndrome." Journal of neurogastroenterology and motility vol. 17,4 (2011): 349-59. doi: https://doi.org/10.5056/jnm.2011.17.4.349
Barbara G, Cremon C, Carini G, Bellacosa L, Zecchi L, De Giorgio R, Corinaldesi R, Stanghellini V. The immune system in irritable bowel syndrome. J Neurogastroenterol Motil. 2011 Oct;17(4):349-59. doi: 10.5056/jnm.2011.17.4.349. Epub 2011 Oct 31. PMID: 22148103; PMCID: PMC3228974.
Copy Download .nbib Format: NLM
Share it on

J Neurogastroenterol Motil. 2011 Oct;17(4):349-59. doi: 10.5056/jnm.2011.17.4.349. Epub 2011 Oct 31.

The immune system in irritable bowel syndrome.

Journal of neurogastroenterology and motility

Giovanni Barbara, Cesare Cremon, Giovanni Carini, Lara Bellacosa, Lisa Zecchi, Roberto De Giorgio, Roberto Corinaldesi, Vincenzo Stanghellini

Affiliations

  1. Department of Clinical Medicine and Center for Applied Biomedical Research University of Bologna, Bologna, Italy. [email protected]

PMID: 22148103 PMCID: PMC3228974 DOI: 10.5056/jnm.2011.17.4.349

Abstract

The potential relevance of systemic and gastrointestinal immune activation in the pathophysiology and symptom generation in the irritable bowel syndrome (IBS) is supported by a number of observations. Infectious gastroenteritis is the strongest risk factor for the development of IBS and increased rates of IBS-like symptoms have been detected in patients with inflammatory bowel disease in remission or in celiac disease patients on a gluten free diet. The number of T cells and mast cells in the small and large intestine of patients with IBS is increased in a large proportion of patients with IBS over healthy controls. Mediators released by immune cells and likely from other non-immune competent cells impact on the function of enteric and sensory afferent nerves as well as on epithelial tight junctions controlling mucosal barrier of recipient animals, isolated human gut tissues or cell culture systems. Antibodies against microbiota antigens (bacterial flagellin), and increased levels of cytokines have been detected systemically in the peripheral blood advocating the existence of abnormal host-microbial interactions and systemic immune responses. Nonetheless, there is wide overlap of data obtained in healthy controls; in addition, the subsets of patients showing immune activation have yet to be clearly identified. Gender, age, geographic differences, genetic predisposition, diet and differences in the intestinal microbiota likely play a role and further research has to be done to clarify their relevance as potential mechanisms in the described immune system dysregulation. Immune activation has stimulated interest for the potential identification of biomarkers useful for clinical and research purposes and the development of novel therapeutic approaches.

Keywords: Abdominal pain; Immune system; Irritable bowel syndrome; Mast cells

References

  1. J Gastroenterol. 2007 Jan;42 Suppl 17:48-51 - PubMed
  2. Gastroenterology. 2007 Jul;133(1):24-33 - PubMed
  3. Scand J Gastroenterol. 2008;43(12):1461-6 - PubMed
  4. Neurogastroenterol Motil. 2000 Oct;12(5):449-57 - PubMed
  5. Gut. 2009 Dec;58(12):1571-5 - PubMed
  6. Gut. 2008 Apr;57(4):468-73 - PubMed
  7. Inflamm Bowel Dis. 2006 Sep;12(9):843-52 - PubMed
  8. Aliment Pharmacol Ther. 2007 Aug 15;26(4):535-44 - PubMed
  9. Bull N Y Acad Med. 1971 Mar;47(3):303-22 - PubMed
  10. Gastroenterology. 2004 Mar;126(3):693-702 - PubMed
  11. Am J Gastroenterol. 2008 Oct;103(10):2570-6 - PubMed
  12. Am J Gastroenterol. 2002 Jun;97(6):1463-7 - PubMed
  13. Trends Mol Med. 2009 Oct;15(10):478-89 - PubMed
  14. Neurogastroenterol Motil. 2009 Jul;21(7):734-e43 - PubMed
  15. Clin Gastroenterol Hepatol. 2007 May;5(5):550-5 - PubMed
  16. Aliment Pharmacol Ther. 2009 Aug;30(3):245-52 - PubMed
  17. Dig Dis Sci. 1993 Sep;38(9):1590-5 - PubMed
  18. Clin Gastroenterol Hepatol. 2008 Feb;6(2):194-205 - PubMed
  19. Aliment Pharmacol Ther. 2003 Jul 1;18(1):77-84 - PubMed
  20. Psychosom Med. 2009 Feb;71(2):171-86 - PubMed
  21. Scand J Gastroenterol. 1995 Jun;30(6):535-41 - PubMed
  22. Scand J Gastroenterol. 2008;43(12):1467-76 - PubMed
  23. Gut. 2010 Mar;59(3):325-32 - PubMed
  24. Gut. 2003 Jan;52(1):91-3 - PubMed
  25. Scand J Rheumatol. 1997;26(4):308-13 - PubMed
  26. Dig Dis. 2009;27 Suppl 1:115-21 - PubMed
  27. Gut. 1998 Jun;42(6):845-9 - PubMed
  28. Gastroenterology. 1989 Sep;97(3):575-85 - PubMed
  29. Gynecol Obstet Invest. 2004;58(3):171-8 - PubMed
  30. Am J Gastroenterol. 2009 May;104(5):1205-12 - PubMed
  31. Inflamm Bowel Dis. 2007 Feb;13(2):175-81 - PubMed
  32. Neurogastroenterol Motil. 2006 Jan;18(1):6-17 - PubMed
  33. World J Gastroenterol. 2009 Dec 21;15(47):5936-45 - PubMed
  34. J Clin Invest. 2007 Jan;117(1):33-40 - PubMed
  35. Pain. 2009 Nov;146(1-2):41-6 - PubMed
  36. Aliment Pharmacol Ther. 2008 Aug 15;28(4):385-96 - PubMed
  37. Gut. 2000 Dec;47(6):804-11 - PubMed
  38. Gastroenterology. 2009 Oct;137(4):1425-34 - PubMed
  39. J Clin Gastroenterol. 2008 Sep;42 Suppl 3 Pt 2:S214-7 - PubMed
  40. Gastroenterology. 2002 Jun;122(7):1778-83 - PubMed
  41. Neurogastroenterol Motil. 2007 Feb;19(2):119-25 - PubMed
  42. Gastroenterology. 2006 Feb;130(2):304-11 - PubMed
  43. Gastroenterology. 2007 Mar;132(3):913-20 - PubMed
  44. J Appl Bacteriol. 1988 Jan;64(1):37-46 - PubMed
  45. Clin Exp Allergy. 1991 Sep;21(5):569-72 - PubMed
  46. Am J Gastroenterol. 2006 Jun;101(6):1288-94 - PubMed
  47. Curr Gastroenterol Rep. 2005 Aug;7(4):264-71 - PubMed
  48. Inflamm Bowel Dis. 2006 Jan;12(1):38-46 - PubMed
  49. J Clin Invest. 2007 Mar;117(3):636-47 - PubMed
  50. Am J Gastroenterol. 2005 Nov;100(11):2510-6 - PubMed
  51. Neurogastroenterol Motil. 2009 Apr;21(4):389-98 - PubMed
  52. Am J Gastroenterol. 2002 Feb;97(2):389-96 - PubMed
  53. J Neurogastroenterol Motil. 2011 Apr;17(2):131-9 - PubMed
  54. Aliment Pharmacol Ther. 2009 Apr 1;29(7):765-73 - PubMed
  55. Urology. 2007 Apr;69(4 Suppl):34-40 - PubMed
  56. Gut. 2008 May;57(5):591-9 - PubMed
  57. Am J Gastroenterol. 2004 Apr;99(4):703-10 - PubMed
  58. Aliment Pharmacol Ther. 2004 Jul;20 Suppl 2:1-9 - PubMed
  59. Gastroenterology. 2006 Apr;130(5):1480-91 - PubMed
  60. Am J Gastroenterol. 2003 Jul;98(7):1578-83 - PubMed
  61. Gastroenterology. 2007 Jan;132(1):26-37 - PubMed
  62. Neurogastroenterol Motil. 2008 Oct;20(10):1110-8 - PubMed
  63. Neurogastroenterol Motil. 2005 Apr;17(2):281-9 - PubMed
  64. Gut. 2004 Aug;53(8):1096-101 - PubMed
  65. Gastroenterology. 2006 Aug;131(2):445-50; quiz 660 - PubMed
  66. Gut. 2007 Feb;56(2):203-9 - PubMed
  67. Am J Gastroenterol. 2009 Feb;104(2):392-400 - PubMed
  68. Gastroenterology. 2010 Apr;138(4):1502-13 - PubMed
  69. Am J Gastroenterol. 2005 Feb;100(2):373-82 - PubMed
  70. Clin Gastroenterol Hepatol. 2005 Oct;3(10):980-6 - PubMed
  71. Arq Gastroenterol. 2013 Oct-Dec;50(4):304-9 - PubMed
  72. Gut. 1980 Oct;21(10):848-50 - PubMed
  73. N Engl J Med. 2011 Jan 6;364(1):22-32 - PubMed
  74. J Steroid Biochem. 1990 Feb;35(2):157-72 - PubMed
  75. Gut. 2009 Feb;58(2):196-201 - PubMed
  76. Am J Gastroenterol. 2010 Apr;105(4):859-65 - PubMed
  77. Nat Rev Immunol. 2009 May;9(5):313-23 - PubMed
  78. Gastroenterology. 2005 Mar;128(3):541-51 - PubMed
  79. Gastroenterology. 2009 May;136(6):2015-31 - PubMed
  80. Gastroenterology. 2003 Dec;125(6):1651-9 - PubMed
  81. Aliment Pharmacol Ther. 2004 Dec;20(11-12):1317-22 - PubMed
  82. Gastroenterology. 2009 May;136(6):1979-88 - PubMed
  83. Gut. 1983 Mar;24(3):190-2 - PubMed
  84. Physiol Rev. 2004 Apr;84(2):579-621 - PubMed
  85. Psychosom Med. 2002 Jan-Feb;64(1):15-28 - PubMed
  86. Gut. 2008 Jul;57(7):923-9 - PubMed
  87. Neurogastroenterol Motil. 2006 Aug;18(8):595-607 - PubMed
  88. Am J Gastroenterol. 2003 Sep;98(9):2023-6 - PubMed

Publication Types