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Katz IR. Depression in late life: psychiatric-medical comorbidity. Dialogues Clin Neurosci. 1999;1(2):81-94
Katz, I. R. (1999). Depression in late life: psychiatric-medical comorbidity. Dialogues in clinical neuroscience, 1(2), 81-94.
Katz, I R. "Depression in late life: psychiatric-medical comorbidity." Dialogues in clinical neuroscience vol. 1,2 (1999): 81-94.
Katz IR. Depression in late life: psychiatric-medical comorbidity. Dialogues Clin Neurosci. 1999 Sep;1(2):81-94. PMID: 22033660; PMCID: PMC3181575.
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Dialogues Clin Neurosci. 1999 Sep;1(2):81-94.

Depression in late life: psychiatric-medical comorbidity.

Dialogues in clinical neuroscience

I R Katz

Affiliations

  1. Section on Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, Pa, USA.

PMID: 22033660 PMCID: PMC3181575

Abstract

The links between late-life depression and the medical comorbidities that are often associated with it can be divided into two paths. The path from medical illness to depression reflects general mechanisms related to stress, disability, and loss, as well as more specific physiological mechanisms, including those related to subclinical cerebrovascular disease, adverse drug effects, and endocrine/metabolic effects. Similarly the path from depression to medical illness includes general mechanisms related to self-neglect, decreased adherence to medical treatments, maladaptive health-related behaviors, and, possibly, more specific physiological mechanisms including those related to altered endocrine and autonomic functions, in the clinical context, these two paths can interact to constitute a vicious cycle. With further research, it should be possible to translate current understanding in these areas into advances in both basic knowledge and treatments that could initiate virtuous cycles with beneficial effects for both menial and physical health.

Keywords: chemically induced depression; cytokine; heart rate; hypercortisolemia; major depression; vascular depression

References

  1. Int Psychogeriatr. 1995 Spring;7(1):63-73 - PubMed
  2. Am J Geriatr Psychiatry. 1996 Summer;4(3):237-246 - PubMed
  3. Arch Neurol. 1992 May;49(5):549-54 - PubMed
  4. Psychother Psychosom. 1997;66(2):63-73 - PubMed
  5. J Neuroendocrinol. 1996 Feb;8(2):129-35 - PubMed
  6. Haematologica. 1989 Mar-Apr;74(2):228 - PubMed
  7. Am J Psychiatry. 1996 Oct;153(10):1313-7 - PubMed
  8. Prev Med. 1994 Sep;23(5):743-50 - PubMed
  9. Am J Psychiatry. 1995 Aug;152(8):1139-44 - PubMed
  10. Brain Res. 1998 Feb 16;784(1-2):355-61 - PubMed
  11. Ann N Y Acad Sci. 1998 Sep 29;856:132-8 - PubMed
  12. Am J Geriatr Psychiatry. 1997 Winter;5(1):15-25 - PubMed
  13. Circulation. 1996 Jun 1;93(11):1976-80 - PubMed
  14. JAMA. 1993 Oct 20;270(15):1819-25 - PubMed
  15. Eur Heart J. 1991 Sep;12(9):959-64 - PubMed
  16. Can J Psychiatry. 1996 Dec;41(10):651-4 - PubMed
  17. Am J Psychiatry. 1996 Oct;153(10):1340-2 - PubMed
  18. Psychosomatics. 1996 Jul-Aug;37(4):380-4 - PubMed
  19. Am J Cardiol. 1996 Sep 15;78(6):613-7 - PubMed
  20. Am J Psychiatry. 1993 Apr;150(4):632-8 - PubMed
  21. Am J Psychiatry. 1998 Feb;155(2):184-91 - PubMed
  22. Arch Gen Psychiatry. 1997 Oct;54(10):915-22 - PubMed
  23. Diabetes Care. 1996 Oct;19(10):1097-102 - PubMed
  24. Am J Psychiatry. 1993 Apr;150(4):546-53 - PubMed
  25. Am J Psychiatry. 1997 Apr;154(4):562-5 - PubMed
  26. JAMA. 1991 Feb 27;265(8):993-6 - PubMed
  27. N Engl J Med. 1986 Jun 26;314(26):1657-64 - PubMed
  28. Psychiatry Res. 1993 Oct;49(1):11-27 - PubMed
  29. Arch Intern Med. 1997 May 26;157(10):1065-8 - PubMed
  30. Arch Neurol. 1995 Oct;52(10):970-4 - PubMed
  31. Psychosom Med. 1996 Mar-Apr;58(2):113-21 - PubMed
  32. Am J Geriatr Psychiatry. 1996 Winter;4(1):1-16 - PubMed
  33. Psychol Med. 1998 Sep;28(5):1015-26 - PubMed
  34. Acta Psychiatr Scand Suppl. 1994;377:77-82 - PubMed
  35. J Neuropsychiatry Clin Neurosci. 1989 Spring;1(2):135-44 - PubMed
  36. Rev Neurosci. 1993 Oct-Dec;4(4):407-16 - PubMed
  37. Epidemiology. 1995 Jul;6(4):366-9 - PubMed
  38. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3908-13 - PubMed
  39. Ann N Y Acad Sci. 1998 May 1;840:717-22 - PubMed
  40. Prog Neuropsychopharmacol Biol Psychiatry. 1995 Jan;19(1):11-38 - PubMed
  41. N Engl J Med. 1996 Oct 17;335(16):1176-81 - PubMed
  42. Dialogues Clin Neurosci. 1999 Sep;1(2):125-8 - PubMed
  43. J Am Geriatr Soc. 1995 Feb;43(2):130-7 - PubMed
  44. J Affect Disord. 1994 Dec;32(4):271-5 - PubMed
  45. Am J Psychiatry. 1994 Aug;151(8):1105-13 - PubMed
  46. Acta Psychiatr Neurol Scand Suppl. 1959;127:1-71 - PubMed
  47. J Gerontol. 1976 May;31(3):300-3 - PubMed
  48. J Gerontol A Biol Sci Med Sci. 1997 Jul;52(4):M201-8 - PubMed
  49. Am J Psychiatry. 1998 Nov;155(11):1605-7 - PubMed
  50. J Clin Psychiatry. 1990 Jul;51 Suppl:41-7; discussion 48 - PubMed
  51. J Clin Epidemiol. 1988;41(3):231-6 - PubMed
  52. Am J Psychiatry. 1990 Apr;147(4):452-6 - PubMed
  53. Psychopharmacol Bull. 1997;33(2):205-17 - PubMed
  54. Am J Psychiatry. 1997 Apr;154(4):497-501 - PubMed
  55. Br J Psychiatry. 1964 Mar;110:244-54 - PubMed
  56. Stroke. 1998 Mar;29(3):613-7 - PubMed
  57. Trends Pharmacol Sci. 1992 Jan;13(1):24-8 - PubMed
  58. Biol Psychiatry. 1997 Aug 15;42(4):290-5 - PubMed
  59. Eur Arch Psychiatry Clin Neurosci. 1993;243(1):41-6 - PubMed
  60. JAMA. 1992 Aug 26;268(8):1018-24 - PubMed
  61. Ann Pharmacother. 1998 Jun;32(6):699-708 - PubMed
  62. J Gerontol. 1992 Jan;47(1):P3-10 - PubMed
  63. Epidemiology. 1993 Jul;4(4):285-94 - PubMed
  64. Ann N Y Acad Sci. 1998 May 1;840:586-90 - PubMed
  65. Am J Psychiatry. 1993 Aug;150(8):1189-93 - PubMed
  66. Arch Neurol. 1995 Oct;52(10):975-81 - PubMed
  67. Circulation. 1996 Dec 15;94(12):3123-9 - PubMed
  68. Am J Cardiol. 1995 Sep 15;76(8):562-4 - PubMed
  69. Semin Oncol. 1998 Feb;25(1 Suppl 1):39-47 - PubMed
  70. Biol Psychiatry. 1997 Mar 15;41(6):724-36 - PubMed
  71. J Neurol Neurosurg Psychiatry. 1994 Nov;57(11):1347-54 - PubMed
  72. J Am Geriatr Soc. 1999 Jan;47(1):6-11 - PubMed
  73. J Gerontol. 1992 Nov;47(6):M189-96 - PubMed
  74. Dialogues Clin Neurosci. 1999 Sep;1(2):68-80 - PubMed
  75. Int J Epidemiol. 1991;20 Suppl 2:S43-7 - PubMed
  76. J Gerontol. 1989 Jan;44(1):M22-9 - PubMed
  77. Am J Geriatr Psychiatry. 1998 Winter;6(1):5-13 - PubMed
  78. Alzheimer Dis Assoc Disord. 1998 Sep;12(3):215-27 - PubMed
  79. Circulation. 1995 Feb 15;91(4):999-1005 - PubMed
  80. Am J Geriatr Psychiatry. 1999 Winter;7(1):18-33 - PubMed
  81. Neuroreport. 1998 Jun 22;9(9):2023-8 - PubMed
  82. Epidemiology. 1996 Sep;7(5):478-84 - PubMed
  83. J Psychosom Res. 1995 Jul;39(5):549-62 - PubMed

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