N Am J Med Sci (Boston). 2011;4(2):104-106. doi: 10.7156/v4i2p104.
North American journal of medicine & science
Kai Li, Jianyuan Luo
PMID: 22180829 PMCID: PMC3237400 DOI: 10.7156/v4i2p104
NAD-dependent Class III histone deacetylase SIRT1 is a multiple functional protein and has been demonstrated critically involved in stress response, cellular metabolism and aging through deacetylating variety of substrates including p53, forkhead transcription factors, PGC-1α, NF-κB, Ku70 and histones. Increasing evidences indicate that SIRT1 plays a complex role in tumorigenesis with functions in both tumor promoting and tumor suppressing. This review provides an overview of current knowledge of SIRT1 and its controversies regarding the functions of SIRT1 in tumorigenesis.