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Mghaieth F, Mizouni H, Mbarki S, et al. Acute myocardial infarction in a patient with hypofibrinogenemia: a case report. J Med Case Rep. 2011;5:582doi: 10.1186/1752-1947-5-582.
Mghaieth, F., Mizouni, H., Mbarki, S., Ayari, J., Trabelsi, R., Moussa, N. B., Mourali, M. S., Mnif, E., & Mechmeche, R. (2011). Acute myocardial infarction in a patient with hypofibrinogenemia: a case report. Journal of medical case reports, 5582. https://doi.org/10.1186/1752-1947-5-582
Mghaieth, Fathia, et al. "Acute myocardial infarction in a patient with hypofibrinogenemia: a case report." Journal of medical case reports vol. 5 (2011): 582. doi: https://doi.org/10.1186/1752-1947-5-582
Mghaieth F, Mizouni H, Mbarki S, Ayari J, Trabelsi R, Moussa NB, Mourali MS, Mnif E, Mechmeche R. Acute myocardial infarction in a patient with hypofibrinogenemia: a case report. J Med Case Rep. 2011 Dec 19;5:582. doi: 10.1186/1752-1947-5-582. PMID: 22182477; PMCID: PMC3261202.
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J Med Case Rep. 2011 Dec 19;5:582. doi: 10.1186/1752-1947-5-582.

Acute myocardial infarction in a patient with hypofibrinogenemia: a case report.

Journal of medical case reports

Fathia Mghaieth, Habiba Mizouni, Sihem Mbarki, Jihen Ayari, Ramy Trabelsi, Nidhal Ben Moussa, Mohamed Sami Mourali, Emna Mnif, Rachid Mechmeche

Affiliations

  1. Service of Cardiology, Rabta University Hospital, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia. [email protected].

PMID: 22182477 PMCID: PMC3261202 DOI: 10.1186/1752-1947-5-582

Abstract

INTRODUCTION: Congenital fibrinogen deficiency is a rare coagulation disorder usually responsible for hemorrhagic diathesis. However, it can be associated with thrombosis and there have been limited reports of arterial thrombotic complications in these patients.

CASE PRESENTATION: A 42-year-old Tunisian man with congenital hypofibrinogenemia and no cardiovascular risk factors presented with new onset prolonged angina pectoris. An electrocardiogram showed features of inferior acute myocardial infarction. His troponin levels had reached 17 ng/L. Laboratory findings confirmed hypofibrinogenemia and ruled out thrombophilia. Echocardiography was not useful in providing diagnostic elements but did show preserved left ventricular function. Coronary angiography was not performed and our patient did not receive any anticoagulant treatment due to the major risk of bleeding. Magnetic resonance imaging confirmed myocardial necrosis. Our patient was managed with aspirin, a beta-blocker, an angiotensin-converting enzyme inhibitor and statin medication. The treatment was well tolerated and no ischemic recurrence was detected.

CONCLUSION: Although coronary thrombosis is a rare event in patients with fibrinogen deficiency, this condition is of major interest in view of the difficulties observed in managing these patients.

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