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Aydin F, Levent Y, Nilgun S, et al. Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy. Indian J Dermatol. 2011;56(5):501-4doi: 10.4103/0019-5154.87130.
Aydin, F., Levent, Y., Nilgun, S., Pancar, Y. E., & Yasar, T. A. (2011). Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy. Indian journal of dermatology, 56(5), 501-4. https://doi.org/10.4103/0019-5154.87130
Aydin, Fatma, et al. "Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy." Indian journal of dermatology vol. 56,5 (2011): 501-4. doi: https://doi.org/10.4103/0019-5154.87130
Aydin F, Levent Y, Nilgun S, Pancar YE, Yasar TA. Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy. Indian J Dermatol. 2011 Sep-Oct;56(5):501-4. doi: 10.4103/0019-5154.87130. PMID: 22121263; PMCID: PMC3221208.
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Indian J Dermatol. 2011 Sep-Oct;56(5):501-4. doi: 10.4103/0019-5154.87130.

Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy.

Indian journal of dermatology

Fatma Aydin, Yildiz Levent, Senturk Nilgun, Yuksel Esra Pancar, Turanli Ahmet Yasar

Affiliations

  1. Ondokuz Mayis University, School of Medicine, Departments of Dermatology and Pathology, Samsun, Turkey.

PMID: 22121263 PMCID: PMC3221208 DOI: 10.4103/0019-5154.87130

Abstract

BACKGROUND: The underlying molecular basis of mycosis fungoides (MF) has not yet been clarified. However, defects in apoptosis may contribute to its pathogenesis.

AIM: We investigated the expression of Bax, Fas, and p53 in early-stage MF patients and any alterations in expression following photochemotherapy.

MATERIALS AND METHODS: Bax, Fas, and p53 expressions were studied by immunohistochemistry in both keratinocytes and lymphocytes on paraffin-embedded skin specimens from 27 early-stage MF patients.

RESULTS: Bax, Fas, and p53 staining was shown in the lymphocytes in 0/27, 26/27, and 11/27 patients at the time of diagnosis, whereas these ratios were 0/27, 9/27, and 0/27, respectively, after psoralen plus ultraviolet A (PUVA) treatment. The decrease in p53 and Fas expression in the lymphocytes was found statistically significant. Bax, Fas, and p53 staining in the keratinocytes was shown in 5/27, 27/27, and 25/27 patients at the time of diagnosis, whereas these ratios were 0/27, 22/27, and 4/27, respectively, after PUVA treatment. The decrease in p53, Fas, and Bax expression in the keratinocytes was found statistically significant.

CONCLUSION: Although Bax seems unrelated with early-stage MF, Fas and p53 expression in the lymphocytes may contribute to the understanding of the pathogenesis of this disease.

Keywords: Apoptosis; Bax; Fas; mycosis fungoides; p53; psoralen plus ultraviolet A

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