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Zhang Q, Claret FX. Phosphatases: the new brakes for cancer development?. Enzyme Res. 2011;2012:659649doi: 10.1155/2012/659649.
Zhang, Q., & Claret, F. X. (2012). Phosphatases: the new brakes for cancer development?. Enzyme research, 2012659649. https://doi.org/10.1155/2012/659649
Zhang, Qingxiu, and Claret, Francois X. "Phosphatases: the new brakes for cancer development?." Enzyme research vol. 2012 (2012): 659649. doi: https://doi.org/10.1155/2012/659649
Zhang Q, Claret FX. Phosphatases: the new brakes for cancer development?. Enzyme Res. 2012;2012:659649. doi: 10.1155/2012/659649. Epub 2011 Oct 31. PMID: 22121480; PMCID: PMC3206369.
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Enzyme Res. 2012;2012:659649. doi: 10.1155/2012/659649. Epub 2011 Oct 31.

Phosphatases: the new brakes for cancer development?.

Enzyme research

Qingxiu Zhang, Francois X Claret

Affiliations

  1. Department of Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

PMID: 22121480 PMCID: PMC3206369 DOI: 10.1155/2012/659649

Abstract

The phosphatidylinositol 3-kinase (PI3K) pathway plays a pivotal role in the maintenance of processes such as cell growth, proliferation, survival, and metabolism in all cells and tissues. Dysregulation of the PI3K/Akt signaling pathway occurs in patients with many cancers and other disorders. This aberrant activation of PI3K/Akt pathway is primarily caused by loss of function of all negative controllers known as inositol polyphosphate phosphatases and phosphoprotein phosphatases. Recent studies provided evidence of distinct functions of the four main phosphatases-phosphatase and tensin homologue deleted on chromosome 10 (PTEN), Src homology 2-containing inositol 5'-phosphatase (SHIP), inositol polyphosphate 4-phosphatase type II (INPP4B), and protein phosphatase 2A (PP2A)-in different tissues with respect to regulation of cancer development. We will review the structures and functions of PTEN, SHIP, INPP4B, and PP2A phosphatases in suppressing cancer progression and their deregulation in cancer and highlight recent advances in our understanding of the PI3K/Akt signaling axis.

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