Display options
Share it on

Hematol Rep. 2010 Jan 26;2(1):e2. doi: 10.4081/hr.2010.e2. Epub 2010 Apr 13.

Pathological basis of symptoms and crises in sickle cell disorder: implications for counseling and psychotherapy.

Hematology reports

Oluwatoyin Olatundun Ilesanmi

Affiliations

  1. Behavioural Studies Department, College of Management Sciences, Redeemer's University, Mowe, Ogun State, Nigeria.

PMID: 22184515 PMCID: PMC3222266 DOI: 10.4081/hr.2010.e2

Abstract

Sickle Cell Disorder (SCD) is a congenital hemoglobinopathy. There is little in literature regarding the psychological variables affecting individuals living with SCD and all of the significant people around them. There are also limited numbers of trained clinical psychologists and genetic counselors to cater for the psychotherapeutic needs of individuals living with SCD. Even among those who have been trained, only a few might have fully grasped the complexities of the disease pathology.Early understanding of its pathological nature, sources, types, complications, pathophysiological basis, and clinical severity of symptoms among clinical psychologists, genetic counselors and psychotherapists, as well as general medical practitioners, could guide them in providing holistic care for dealing with and reducing pain among individuals living with SCD. It could allow risk-based counseling for families and individuals. It could also justify the early use of disease-modifying or curative interventions, such as hydroxyurea (HU), chronic transfusions (CTs), or stem-cell transplantation (SCT) by general medical practitioners. Hence, the need for this paper on the pathophysiology of SCD.

Keywords: counseling and psychotherapy.; implications; pathology; sickle cell disorder

References

  1. N Engl J Med. 2004 Feb 26;350(9):886-95 - PubMed
  2. Blood. 2001 Jun 1;97(11):3411-6 - PubMed
  3. Science. 1949 Nov 25;110(2865):543-8 - PubMed
  4. N Engl J Med. 1997 Sep 11;337(11):762-9 - PubMed
  5. Curr Opin Hematol. 1997 Nov;4(6):377-80 - PubMed
  6. J Clin Invest. 1982 Dec;70(6):1253-9 - PubMed
  7. Circ Res. 2000 Nov 10;87(10):840-4 - PubMed
  8. Curr Opin Pediatr. 2001 Feb;13(1):22-7 - PubMed
  9. Am Heart J. 1999 Aug;138(2 Pt 1):384 - PubMed
  10. Turk J Gastroenterol. 2006 Sep;17(3):252-5 - PubMed
  11. Nature. 1957 Aug 17;180(4581):326-8 - PubMed
  12. J Physiol. 1998 Aug 15;511 ( Pt 1):225-34 - PubMed
  13. Lancet. 2002 Jul 13;360(9327):141-3 - PubMed
  14. J Membr Biol. 1998 Dec 1;166(3):157-67 - PubMed
  15. J Clin Invest. 2005 Dec;115(12):3355-62 - PubMed
  16. Br J Haematol. 2000 Nov;111(2):474-81 - PubMed
  17. J Lab Clin Med. 1984 Apr;103(4):589-96 - PubMed
  18. Pediatrics. 2000 Aug;106(2 Pt 1):362-6 - PubMed
  19. Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1626-31 - PubMed
  20. Lancet. 1997 Sep 6;350(9079):725-30 - PubMed
  21. Yale J Biol Med. 2001 May-Jun;74(3):179-84 - PubMed
  22. J Biol Chem. 1998 Jul 24;273(30):18709-13 - PubMed
  23. East Afr Med J. 1998 Jun;75(6):347-50 - PubMed
  24. Semin Hematol. 1990 Jan;27(1):51-69 - PubMed
  25. Ann Intern Med. 1991 Oct 15;115(8):614-20 - PubMed
  26. Biochim Biophys Acta. 1999 May 5;1411(2-3):217-30 - PubMed
  27. JAMA. 2003 Apr 2;289(13):1645-51 - PubMed
  28. Biochem Biophys Res Commun. 2000 Apr 29;271(1):217-21 - PubMed
  29. N Engl J Med. 2000 Jan 13;342(2):83-9 - PubMed
  30. N Engl J Med. 2003 Apr 10;348(15):1483-5 - PubMed
  31. Free Radic Biol Med. 2000 May 15;28(10):1518-25 - PubMed
  32. Hepatology. 2001 May;33(5):1021-8 - PubMed
  33. Hum Pathol. 2002 Oct;33(10):1037-43 - PubMed
  34. Reg Anesth. 1989 Jul-Aug;14(4):162-79 - PubMed
  35. Am J Clin Nutr. 2002 Jun;75(6):1093-7 - PubMed
  36. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9265-9 - PubMed
  37. Hematology. 2003 Oct;8(5):329-37 - PubMed
  38. Am J Obstet Gynecol. 2006 May;194(5):1311-5 - PubMed
  39. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8757-61 - PubMed
  40. Hemoglobin. 1995;19(6):323-33 - PubMed
  41. Curr Opin Clin Nutr Metab Care. 2001 Jan;4(1):65-71 - PubMed
  42. Liver Transpl. 2007 Apr;13(4):505-8 - PubMed
  43. Br Med J. 1954 Feb 6;1(4857):290-4 - PubMed
  44. Am J Physiol. 1977 Sep;233(3):169-84 - PubMed
  45. J Lab Clin Med. 1999 Oct;134(4):352-62 - PubMed
  46. Am J Clin Nutr. 2004 Jul;80(1):101-7 - PubMed
  47. Transfusion. 2002 Jan;42(1):37-43 - PubMed
  48. Am J Hematol. 2005 May;79(1):17-25 - PubMed
  49. Arch Pathol Lab Med. 1995 Jan;119(1):46-52 - PubMed
  50. Blood Coagul Fibrinolysis. 1991 Apr;2(2):341-53 - PubMed
  51. Br J Haematol. 1980 Jan;44(1):87-92 - PubMed
  52. Transfusion. 1996 Nov-Dec;36(11-12):960-5 - PubMed
  53. Free Radic Biol Med. 2004 Mar 15;36(6):685-97 - PubMed
  54. Am J Med. 2006 Oct;119(10):897.e7-11 - PubMed
  55. N Engl J Med. 1995 May 18;332(20):1317-22 - PubMed
  56. J Clin Invest. 2003 Jan;111(2):231-9 - PubMed
  57. J Biol Chem. 1979 Feb 25;254(4):1178-90 - PubMed
  58. J Lab Clin Med. 2002 Feb;139(2):80-9 - PubMed
  59. Clin Adv Hematol Oncol. 2005 Jun;3(6):492-505 - PubMed
  60. Blood. 1998 Jun 1;91(11):4373-8 - PubMed
  61. J Nutr. 1992 Nov;122(11):2066-73 - PubMed
  62. Ann Neurol. 2002 May;51(5):543-52 - PubMed
  63. Clin Sci (Lond). 1989 Jul;77(1):93-7 - PubMed
  64. Pediatr Blood Cancer. 2005 Aug;45(2):184-90 - PubMed
  65. J Lab Clin Med. 2001 Jun;137(6):398-407 - PubMed

Publication Types