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Ortín X, Rodríguez-Luaces M, Bosch R, et al. Acute liver failure as the first manifestation of very late relapsing of Hodgkin's disease. Hematol Rep. 2010;2(1):e5doi: 10.4081/hr.2010.e5.
Ortín, X., Rodríguez-Luaces, M., Bosch, R., Lejeune, M., & Font, L. (2010). Acute liver failure as the first manifestation of very late relapsing of Hodgkin's disease. Hematology reports, 2(1), e5. https://doi.org/10.4081/hr.2010.e5
Ortín, Xavier, et al. "Acute liver failure as the first manifestation of very late relapsing of Hodgkin's disease." Hematology reports vol. 2,1 (2010): e5. doi: https://doi.org/10.4081/hr.2010.e5
Ortín X, Rodríguez-Luaces M, Bosch R, Lejeune M, Font L. Acute liver failure as the first manifestation of very late relapsing of Hodgkin's disease. Hematol Rep. 2010 Jan 26;2(1):e5. doi: 10.4081/hr.2010.e5. Epub 2010 Jul 23. PMID: 22184518; PMCID: PMC3222269.
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Hematol Rep. 2010 Jan 26;2(1):e5. doi: 10.4081/hr.2010.e5. Epub 2010 Jul 23.

Acute liver failure as the first manifestation of very late relapsing of Hodgkin's disease.

Hematology reports

Xavier Ortín, Marta Rodríguez-Luaces, Ramon Bosch, Marylene Lejeune, Llorenç Font

Affiliations

  1. Servicio de Hematología, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain;

PMID: 22184518 PMCID: PMC3222269 DOI: 10.4081/hr.2010.e5

Abstract

Hodgkin's disease is, in general, a lymph node-based disease. It usually starts in an area within the lymphatic system and spreads, in an orderly manner, along the lymphatic chain to contiguous lymph node areas. There have been sporadic case reports of acute liver failure caused by hematological malignancies. Generally, liver failure is a feature of stage IV end-stage disease, when it occurs in lymphoma. Thus, hepatic involvement usually occurs late in the course of Hodgkin's disease or with advanced-stage disease, and primary presentation in the liver with acute liver failure is extremely rare. In most cases, the diagnosis was made at autopsy. We describe a patient with Hodgkin's disease presenting with acute liver failure. This is a very unusual Hodgkin's disease form of presentation, because the acute liver failure was the presenting feature of the disease. Furthermore, the lymphoma occurred as a very late relapse, twenty years after the first diagnosis. To the best of our knowledge, such a case has not been described to date.

Keywords: Hodgkin's disease.; acute liver failure

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