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Alarfaj NA, Ammar RA, El-Tohamy MF. Disposable screen-printed sensors for determination of duloxetine hydrochloride. Chem Cent J. 2012;6:6doi: 10.1186/1752-153X-6-6.
Alarfaj, N. A., Ammar, R. A., & El-Tohamy, M. F. (2012). Disposable screen-printed sensors for determination of duloxetine hydrochloride. Chemistry Central journal, 66. https://doi.org/10.1186/1752-153X-6-6
Alarfaj, Nawal A, et al. "Disposable screen-printed sensors for determination of duloxetine hydrochloride." Chemistry Central journal vol. 6 (2012): 6. doi: https://doi.org/10.1186/1752-153X-6-6
Alarfaj NA, Ammar RA, El-Tohamy MF. Disposable screen-printed sensors for determination of duloxetine hydrochloride. Chem Cent J. 2012 Jan 21;6:6. doi: 10.1186/1752-153X-6-6. PMID: 22264225; PMCID: PMC3275491.
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Chem Cent J. 2012 Jan 21;6:6. doi: 10.1186/1752-153X-6-6.

Disposable screen-printed sensors for determination of duloxetine hydrochloride.

Chemistry Central journal

Nawal A Alarfaj, Reda A Ammar, Maha F El-Tohamy

Affiliations

  1. Department of Chemistry, College of Science, King Saud University, P,O, Box 22452, Riyadh 11495, Saudi Arabia. [email protected].

PMID: 22264225 PMCID: PMC3275491 DOI: 10.1186/1752-153X-6-6

Abstract

A screen-printed disposable electrode system for the determination of duloxetine hydrochloride (DL) was developed using screen-printing technology. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrodes was used as duloxetine hydrochloride sensor. The proposed sensors worked satisfactorily in the concentration range from 1.0 × 10-6-1.0 × 10-2 mol L-1 with detection limit reaching 5.0 × 10-7 mol L-1 and adequate shelf life of 6 months. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically by recovery studies.

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