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Lohans CT, Vederas JC. Development of Class IIa Bacteriocins as Therapeutic Agents. Int J Microbiol. 2011;2012:386410doi: 10.1155/2012/386410.
Lohans, C. T., & Vederas, J. C. (2012). Development of Class IIa Bacteriocins as Therapeutic Agents. International journal of microbiology, 2012386410. https://doi.org/10.1155/2012/386410
Lohans, Christopher T, and Vederas, John C. "Development of Class IIa Bacteriocins as Therapeutic Agents." International journal of microbiology vol. 2012 (2012): 386410. doi: https://doi.org/10.1155/2012/386410
Lohans CT, Vederas JC. Development of Class IIa Bacteriocins as Therapeutic Agents. Int J Microbiol. 2012;2012:386410. doi: 10.1155/2012/386410. Epub 2011 Nov 30. PMID: 22187559; PMCID: PMC3236453.
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Int J Microbiol. 2012;2012:386410. doi: 10.1155/2012/386410. Epub 2011 Nov 30.

Development of Class IIa Bacteriocins as Therapeutic Agents.

International journal of microbiology

Christopher T Lohans, John C Vederas

Affiliations

  1. Department of Chemistry, University of Alberta, Edmonton, AB, Canada T6G 2G2.

PMID: 22187559 PMCID: PMC3236453 DOI: 10.1155/2012/386410

Abstract

Class IIa bacteriocins have been primarily explored as natural food preservatives, but there is much interest in exploring the application of these peptides as therapeutic antimicrobial agents. Bacteriocins of this class possess antimicrobial activity against several important human pathogens. Therefore, the therapeutic development of these bacteriocins will be reviewed. Biological and chemical modifications to both stabilize and increase the potency of bacteriocins are discussed, as well as the optimization of their production and purification. The suitability of bacteriocins as pharmaceuticals is explored through determinations of cytotoxicity, effects on the natural microbiota, and in vivo efficacy in mouse models. Recent results suggest that class IIa bacteriocins show promise as a class of therapeutic agents.

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