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Case Rep Neurol. 2011 Sep;3(3):294-300. doi: 10.1159/000335004. Epub 2011 Dec 05.

An Autopsy Case of Amyotrophic Lateral Sclerosis with Waldenström Macroglobulinemia and Anti-MAG Gammopathy.

Case reports in neurology

Snejana Jurici, Annie Laquerrière, Anne-Laure Bedat-Millet, Fabrice Jardin, Lucile Musset, Jean-Michel Vallat, Didier Hannequin, Olivier Martinaud

Affiliations

  1. Department of Neurology, Faculty of Medicine and Pharmacy, Rouen.

PMID: 22220157 PMCID: PMC3250649 DOI: 10.1159/000335004

Abstract

We report the case of a 71-year-old woman with typical signs of bulbar amyotrophic lateral sclerosis (ALS) associated with immunoglobulin M (IgM) monoclonal gammopathy and anti-MAG (myelin-associated glycoprotein) antibodies. This unusual association between ALS and anti-MAG antibodies has previously been reported in a single case. Our present case, at neuropathological examination, demonstrated no causative link between anti-MAG antibodies and ALS.

Keywords: Amyotrophic lateral sclerosis; Anti-MAG; Waldenström macroglobulinemia

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