Display options
Cite
Jiang ZE, Shin BN, Kim IH, et al. Roles of Non-cholinergic Intrapancreatic Nerves, Serotonergic Nerves, on Pancreatic Exocrine Secretion in the Isolated Perfused Rat Pancreas. Korean J Physiol Pharmacol. 2011;15(5):307-12doi: 10.4196/kjpp.2011.15.5.307.
Jiang, Z. E., Shin, B. N., Kim, I. H., Lee, H. J., Yong, J. H., Lee, M. J., Won, M. H., & Lee, Y. L. (2011). Roles of Non-cholinergic Intrapancreatic Nerves, Serotonergic Nerves, on Pancreatic Exocrine Secretion in the Isolated Perfused Rat Pancreas. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 15(5), 307-12. https://doi.org/10.4196/kjpp.2011.15.5.307
Jiang, Zheng Er, et al. "Roles of Non-cholinergic Intrapancreatic Nerves, Serotonergic Nerves, on Pancreatic Exocrine Secretion in the Isolated Perfused Rat Pancreas." The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 15,5 (2011): 307-12. doi: https://doi.org/10.4196/kjpp.2011.15.5.307
Jiang ZE, Shin BN, Kim IH, Lee HJ, Yong JH, Lee MJ, Won MH, Lee YL. Roles of Non-cholinergic Intrapancreatic Nerves, Serotonergic Nerves, on Pancreatic Exocrine Secretion in the Isolated Perfused Rat Pancreas. Korean J Physiol Pharmacol. 2011 Oct;15(5):307-12. doi: 10.4196/kjpp.2011.15.5.307. Epub 2011 Oct 31. PMID: 22128264; PMCID: PMC3222801.
Copy Download .nbib Format: NLM
Share it on

Korean J Physiol Pharmacol. 2011 Oct;15(5):307-12. doi: 10.4196/kjpp.2011.15.5.307. Epub 2011 Oct 31.

Roles of Non-cholinergic Intrapancreatic Nerves, Serotonergic Nerves, on Pancreatic Exocrine Secretion in the Isolated Perfused Rat Pancreas.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Zheng Er Jiang, Bich-Na Shin, In-Hye Kim, Hyun Joo Lee, Jun-Hwan Yong, Min-Jae Lee, Moo-Ho Won, Yun-Lyul Lee

Affiliations

  1. Department of Physiology, College of Nursing, Yanbian University, Yanji 133000, China.

PMID: 22128264 PMCID: PMC3222801 DOI: 10.4196/kjpp.2011.15.5.307

Abstract

It has been rereported that axons which display 5-hydroxytryptamine (5-HT) immunoreactivity are abundant in the pancreas and the majority of serotonergic axons terminate within intrapancreatic ganglia, islet and acini. This histological result strongly suggests that intrapancreatic serotonergic nerves could affect to the pancreatic endocrine and exocrine secretion. Thus, this study was aimed to investigate whether intrapancreatic serotonergic nerves could affect pancreatic exocrine secretion and an action mechanism of the intrapancreatic serotonergic nerves. The rats were anesthetized with a single injection of urethane. The median line and the abdominal aorta was carefully dissected and cannulated with PE-50 tubing just above the celiac artery, and then tightly ligated just below the superior mesenteric artery. The pancreatic duct was also cannulated with Tygon microbore tubing. With the addition of serotonin, pancreatic volume flow and amylase output were significantly inhibited electrical field stimulation (EFS). On the other hand, pancreatic volume flow and amylase output were significantly elevated in EFS with the addition of spiperone. EFS application, however, pancreatic volume flow and amylase output had no significant change in cholecystokinin (CCK) alone when serotonin was applied under a 5.6 mM glucose background. Pancreatic volume flow and amylase output under 18 mM glucose background were significantly elevated in CCK plus serotonin than in CCK alone. These data suggest that intrapancreatic serotonergic nerves play an inhibitory role in pancreatic exocrine secretion and an important role in the insulin action or release.

Keywords: 5-hydroxytryptamine; Cholecystokinin; Electrical stimulation; Insulin; Intrapancreatic nerve

References

  1. J Auton Nerv Syst. 1997 Jan 12;62(1-2):58-62 - PubMed
  2. Neuro Endocrinol Lett. 1999;20(5):315-322 - PubMed
  3. Gastroenterology. 1993 Jul;105(1):221-8 - PubMed
  4. Am J Physiol. 1985 Jul;249(1 Pt 1):E43-8 - PubMed
  5. Korean J Physiol Pharmacol. 2011 Feb;15(1):53-9 - PubMed
  6. Am J Physiol. 1998 Feb;274(2):E317-20 - PubMed
  7. J Physiol Pharmacol. 2001 Dec;52(4 Pt 1):523-38 - PubMed
  8. J Comp Neurol. 1996 Jan 15;364(3):439-455 - PubMed
  9. Am J Physiol Gastrointest Liver Physiol. 2001 Apr;280(4):G595-602 - PubMed
  10. Am J Physiol. 1998 Feb;274(2):G413-8 - PubMed
  11. J Neurosci. 1990 May;10(5):1626-42 - PubMed
  12. Curr Opin Gastroenterol. 2001 Mar;17(2):99-103 - PubMed
  13. J Pineal Res. 1997 Oct;23(3):156-63 - PubMed
  14. Am J Physiol. 1994 Aug;267(2 Pt 1):G207-12 - PubMed
  15. Pflugers Arch. 1999 Mar;437(4):511-6 - PubMed
  16. J Hirnforsch. 1995;36(1):77-100 - PubMed
  17. Pancreas. 1996 Jan;12(1):58-63 - PubMed
  18. J Physiol. 1993 Apr;463:421-9 - PubMed
  19. Pancreas. 1991 Jan;6(1):1-8 - PubMed
  20. Am J Physiol Gastrointest Liver Physiol. 2000 Apr;278(4):G557-62 - PubMed
  21. Am J Physiol. 1992 Dec;263(6 Pt 1):G838-46 - PubMed
  22. Pancreas. 1999 Jul;19(1):56-61 - PubMed

Publication Types