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Lou HY, Fang CL, Fang SU, et al. Hepatic failure related to itraconazole use successfully treated by corticosteroids. Hepat Mon. 2011;11(10):843-6doi: 10.5812/kowsar.1735143X.755.
Lou, H. Y., Fang, C. L., Fang, S. U., Tiong, C., Cheng, Y. C., & Chang, C. C. (2011). Hepatic failure related to itraconazole use successfully treated by corticosteroids. Hepatitis monthly, 11(10), 843-6. https://doi.org/10.5812/kowsar.1735143X.755
Lou, Horng-Yuan, et al. "Hepatic failure related to itraconazole use successfully treated by corticosteroids." Hepatitis monthly vol. 11,10 (2011): 843-6. doi: https://doi.org/10.5812/kowsar.1735143X.755
Lou HY, Fang CL, Fang SU, Tiong C, Cheng YC, Chang CC. Hepatic failure related to itraconazole use successfully treated by corticosteroids. Hepat Mon. 2011 Oct;11(10):843-6. doi: 10.5812/kowsar.1735143X.755. PMID: 22224084; PMCID: PMC3234573.
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Hepat Mon. 2011 Oct;11(10):843-6. doi: 10.5812/kowsar.1735143X.755.

Hepatic failure related to itraconazole use successfully treated by corticosteroids.

Hepatitis monthly

Horng-Yuan Lou, Chia-Lang Fang, Sheng-Uei Fang, Cheng Tiong, Yang-Chih Cheng, Chun-Chao Chang

Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.

PMID: 22224084 PMCID: PMC3234573 DOI: 10.5812/kowsar.1735143X.755

Abstract

BACKGROUND: Itraconazole is believed to carry a low risk of hepatic toxicity owing to its low affinity for the human P-450 enzyme. Therefore, hepatic failure caused by itraconazole is exceedingly rare.

OBJECTIVES: We report the case of a 46-year-old woman who developed hepatic failure related to itraconazole that was administered for the treatment of onychomycosis. Her condition deteriorated after withdrawal of the drug, followed solely by supportive care initially.

CASE REPORT: Treatment with corticosteroids was started 10 days after her admission, and her condition gradually improved. Unfortunately, her condition worsened when the dosage of corticosteroids was abruptly decreased. Ultimately, her condition improved with appropriate adjustments of corticosteroid dosage.

DISCUSSION: We conclude that corticosteroid therapy may be effective for itraconazole-induced hepatitis, especially in those patients who do not respond to conservative treatment. Notably, any decrease in the dosage should be performed with caution. We also recommend that close monitoring of liver function is mandatory during the use of itraconazole.

Keywords: Adrenal Cortex Hormones; Itraconazole; Liver Failure

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