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Bentzen BH, Grunnet M. Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal. Adv Pharmacol Sci. 2011;2011:578273doi: 10.1155/2011/578273.
Bentzen, B. H., & Grunnet, M. (2011). Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal. Advances in pharmacological sciences, 2011578273. https://doi.org/10.1155/2011/578273
Bentzen, Bo Hjorth, and Grunnet, Morten. "Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal." Advances in pharmacological sciences vol. 2011 (2011): 578273. doi: https://doi.org/10.1155/2011/578273
Bentzen BH, Grunnet M. Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal. Adv Pharmacol Sci. 2011;2011:578273. doi: 10.1155/2011/578273. Epub 2011 Nov 17. PMID: 22162673; PMCID: PMC3226329.
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Adv Pharmacol Sci. 2011;2011:578273. doi: 10.1155/2011/578273. Epub 2011 Nov 17.

Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal.

Advances in pharmacological sciences

Bo Hjorth Bentzen, Morten Grunnet

Affiliations

  1. NeuroSearch A/S, Pederstrupvej 93, 2750 Ballerup, Denmark.

PMID: 22162673 PMCID: PMC3226329 DOI: 10.1155/2011/578273

Abstract

Intuitively one might expect that activation of GABAergic inhibitory neurons results in bradycardia. In conscious animals the opposite effect is however observed. GABAergic neurons in nucleus ambiguus hold the ability to control the activity of the parasympathetic vagus nerve that innervates the heart. Upon GABA activation the vagus nerve will be inhibited leaving less parasympathetic impact on the heart. The picture is however blurred in the presence of anaesthesia where both the concentration and type of anaesthetics can result in different effects on the cardiovascular system. This paper reviews cardiovascular outcomes of GABA activation and includes own experiments on anaesthetized animals and isolated hearts. In conclusion, the impact of changes in GABAergic input is very difficult to predict in these settings, emphasizing the need for experiments performed in conscious animals when aiming at determining the cardiovascular effects of compounds acting on GABAergic neurons.

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