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Dunlap K, Holz GG, Rane SG. G proteins as regulators of ion channel function. Trends Neurosci. 1987;10(6):241-244doi: 10.1016/0166-2236(87)90166-4.
Dunlap, K., Holz, G. G., & Rane, S. G. (1987). G proteins as regulators of ion channel function. Trends in neurosciences, 10(6), 241-244. https://doi.org/10.1016/0166-2236(87)90166-4
Dunlap, Kathleen, et al. "G proteins as regulators of ion channel function." Trends in neurosciences vol. 10,6 (1987): 241-244. doi: https://doi.org/10.1016/0166-2236(87)90166-4
Dunlap K, Holz GG, Rane SG. G proteins as regulators of ion channel function. Trends Neurosci. 1987 Jun 01;10(6):241-244. doi: 10.1016/0166-2236(87)90166-4. PMID: 22241937; PMCID: PMC3254587.
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Trends Neurosci. 1987 Jun 01;10(6):241-244. doi: 10.1016/0166-2236(87)90166-4.

G proteins as regulators of ion channel function.

Trends in neurosciences

Kathleen Dunlap, George G Holz, Stanley G Rane

Affiliations

  1. Department of Physiology, Tufts University School of Medicine, Boston, MA 02111, USA.

PMID: 22241937 PMCID: PMC3254587 DOI: 10.1016/0166-2236(87)90166-4

Abstract

Virtually unknown just a decade ago, GTP-binding proteins (G proteins) have become a major focus of current research. This family of closely related proteins transduce extracellular signals (such as hormones, neurotransmitters and sensory stimuli) into effector responses (1,2). It is now evident that ion channel permeability is one such effector response. In fact, the striking increase in the frequency of reports that demonstrate G protein-regulated ion channel function suggests that channels whose permeability mechanism can be altered by a G protein-mediated process may be more the rule than the exception. It is well-known that the cAMP-dependent modulation of ion channels is under the control of G proteins that regulate adenylate cyclase activity(3,4). However recent studies demonstrate that G proteins also transduce agonist-induced changes in channel activity that do not involve adenylate cyclase. It is on this aspect of G protein signal transduction that this review will focus.

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