Display options
Cite
Kitahara CM, Platz EA, Beane Freeman LE, et al. Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies. Cancer Causes Control. 2012;23(3):463-471doi: 10.1007/s10552-012-9896-y.
Kitahara, C. M., Platz, E. A., Beane Freeman, L. E., Black, A., Hsing, A. W., Linet, M. S., Park, Y., Schairer, C., & Berrington de González, A. (2012). Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies. Cancer causes & control : CCC, 23(3), 463-471. https://doi.org/10.1007/s10552-012-9896-y
Kitahara, Cari M, et al. "Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies." Cancer causes & control : CCC vol. 23,3 (2012): 463-471. doi: https://doi.org/10.1007/s10552-012-9896-y
Kitahara CM, Platz EA, Beane Freeman LE, Black A, Hsing AW, Linet MS, Park Y, Schairer C, Berrington de González A. Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies. Cancer Causes Control. 2012 Mar;23(3):463-471. doi: 10.1007/s10552-012-9896-y. Epub 2012 Feb 01. PMID: 22294499; PMCID: PMC3586378.
Copy Download .nbib Format: NLM
Share it on

Cancer Causes Control. 2012 Mar;23(3):463-471. doi: 10.1007/s10552-012-9896-y. Epub 2012 Feb 01.

Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies.

Cancer causes & control : CCC

Cari M Kitahara, Elizabeth A Platz, Laura E Beane Freeman, Amanda Black, Ann W Hsing, Martha S Linet, Yikyung Park, Catherine Schairer, Amy Berrington de González

Affiliations

  1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, EPS 7056, 6120 Executive Blvd, Rockville, MD, 20852, USA, [email protected].

PMID: 22294499 PMCID: PMC3586378 DOI: 10.1007/s10552-012-9896-y

Abstract

PURPOSE: Although many studies have linked obesity with increased risk of thyroid cancer, few have investigated the role of obesity-related lifestyle characteristics and medical conditions in the etiology of this disease. We examined the associations of self-reported physical activity and diabetes history with thyroid cancer risk in a large pooled analysis of prospective cohort studies. METHODS: Data from five prospective studies in the U.S. (n = 362,342 men, 312,149 women) were coded using standardized exposure, covariate, and outcome definitions. Hazard ratios (HR) and 95% confidence intervals (CI) for thyroid cancer were estimated using age as the time metric and adjusting for sex, education, race, marital status, cigarette smoking, body mass index, alcohol intake, and cohort. Effect modification by other risk factors (e.g., age, sex, and body mass index) and differences by cancer subtype (e.g., papillary, follicular) were also examined. RESULTS: Over follow-up (median = 10.5 years), 308 men and 510 women were diagnosed with a first primary thyroid cancer. Overall, subjects reporting the greatest amount of physical activity had an increased risk of the disease (HR = 1.18, 95% CI:1.00-1.39); however, this association was restricted to participants who were overweight/obese (≥25 kg/m(2); HR = 1.34, 95% CI:1.09-1.64) as opposed to normal-weight (<25 kg/m(2); HR = 0.92, 95% CI:0.69-1.22; P-interaction = 0.03). We found no overall association between self-reported history of diabetes and thyroid cancer risk (HR = 1.08, 95% CI:0.83-1.40). CONCLUSION: Neither physical inactivity nor diabetes history was associated with increased risk of thyroid cancer. While it may have been a chance finding, the possible increased risk associated with greater physical activity warrants further investigation.

References

  1. Control Clin Trials. 1986 Sep;7(3):177-88 - PubMed
  2. Cancer Causes Control. 2008 Dec;19(10):1233-42 - PubMed
  3. Cancer Epidemiol Biomarkers Prev. 2009 Mar;18(3):784-91 - PubMed
  4. Cancer Causes Control. 2009 Jul;20(5):581-90 - PubMed
  5. Thyroid. 2011 Sep;21(9):957-63 - PubMed
  6. Am J Epidemiol. 2007 Nov 15;166(10):1140-9 - PubMed
  7. Int J Cancer. 2010 Jun 15;126(12):2984-90 - PubMed
  8. Diabetes. 2008 Oct;57(10):2613-8 - PubMed
  9. Br J Cancer. 2006 Aug 7;95(3):366-70 - PubMed
  10. Int J Cancer. 2010 Jun 15;126(12):2947-56 - PubMed
  11. Am J Epidemiol. 2010 Jan 15;171(2):242-52 - PubMed
  12. Diabetologia. 2006 May;49(5):945-52 - PubMed
  13. JAMA. 2010 Jan 20;303(3):235-41 - PubMed
  14. Cancer Causes Control. 2000 Feb;11(2):137-44 - PubMed
  15. Cancer Causes Control. 2006 Sep;17(7):901-9 - PubMed
  16. Cancer Causes Control. 2001 Dec;12(10):881-5 - PubMed
  17. Environ Health Perspect. 1998 Aug;106(8):427-36 - PubMed
  18. Cancer Epidemiol Biomarkers Prev. 1997 Nov;6(11):863-73 - PubMed
  19. J Clin Oncol. 2005 Jul 20;23(21):4742-54 - PubMed
  20. Cancer Epidemiol Biomarkers Prev. 2011 Mar;20(3):464-72 - PubMed
  21. Best Pract Res Clin Endocrinol Metab. 2008 Aug;22(4):659-69 - PubMed
  22. Int J Cancer. 2001 Sep 1;93(5):745-50 - PubMed
  23. Diabetes Care. 2010 Jul;33(7):1674-85 - PubMed
  24. Psychol Methods. 2006 Jun;11(2):193-206 - PubMed
  25. Am J Epidemiol. 2007 Oct 1;166(7):832-40 - PubMed
  26. Br J Cancer. 2005 Oct 31;93(9):1062-7 - PubMed

Publication Types

Grant support