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Albano E. Role of adaptive immunity in alcoholic liver disease. Int J Hepatol. 2011;2012:893026doi: 10.1155/2012/893026.
Albano, E. (2012). Role of adaptive immunity in alcoholic liver disease. International journal of hepatology, 2012893026. https://doi.org/10.1155/2012/893026
Albano, Emanuele. "Role of adaptive immunity in alcoholic liver disease." International journal of hepatology vol. 2012 (2012): 893026. doi: https://doi.org/10.1155/2012/893026
Albano E. Role of adaptive immunity in alcoholic liver disease. Int J Hepatol. 2012;2012:893026. doi: 10.1155/2012/893026. Epub 2011 Sep 07. PMID: 22229098; PMCID: PMC3168273.
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Int J Hepatol. 2012;2012:893026. doi: 10.1155/2012/893026. Epub 2011 Sep 07.

Role of adaptive immunity in alcoholic liver disease.

International journal of hepatology

Emanuele Albano

Affiliations

  1. Department of Medical Sciences and Interdisciplinary Research Centre for Autoimmune Diseases (IRCAD), University "Amedeo Avogadro" of East Piedmont, Via Solaroli 17, 28100 Novara, Italy.

PMID: 22229098 PMCID: PMC3168273 DOI: 10.1155/2012/893026

Abstract

Stimulation of innate immunity is increasingly recognized to play an important role in the pathogenesis of alcoholic liver disease (ALD), while the contribution of adaptive immunity has received less attention. Clinical and experimental data show the involvement of Th-1 and Th-17 T-lymphocytes in alcoholic hepatitis. Nonetheless, the mechanisms by which alcohol triggers adaptive immunity are still incompletely characterized. Patients with advanced ALD have circulating IgG and T-lymphocytes recognizing epitopes derived from protein modification by hydroxyethyl free radicals and end products of lipid-peroxidation. High titers of IgG against lipid peroxidation-derived antigens are associated with an increased hepatic production of proinflammatory cytokines/chemokines. Moreover, the same antigens favor the breaking of self-tolerance towards liver constituents. In particular, autoantibodies against cytochrome P4502E1 (CYP2E1) are evident in a subset of ALD patients. Altogether these results suggest that allo- and autoimmune reactions triggered by oxidative stress might contribute to hepatic inflammation during the progression of ALD.

References

  1. Gastroenterology. 1992 Dec;103(6):1860-7 - PubMed
  2. J Hepatol. 2001 Feb;34(2):248-53 - PubMed
  3. Apoptosis. 2006 Oct;11(10):1709-26 - PubMed
  4. Clin Dev Immunol. 2011;2011:345803 - PubMed
  5. J Leukoc Biol. 2002 Dec;72(6):1109-16 - PubMed
  6. J Biol Chem. 2010 Jul 16;285(29):22211-20 - PubMed
  7. Hepatology. 1996 Jan;23(1):155-63 - PubMed
  8. Immunol Rev. 2005 Apr;204:102-15 - PubMed
  9. Alcohol Clin Exp Res. 2011 May;35(5):787-93 - PubMed
  10. Alcohol. 2001 Jul;24(3):155-67 - PubMed
  11. Hepatology. 1995 Jul;22(1):355-7 - PubMed
  12. Mol Pharmacol. 1994 Oct;46(4):786-91 - PubMed
  13. Curr Med Chem. 2008;15(22):2285-92 - PubMed
  14. Hepatology. 2009 Aug;50(2):638-44 - PubMed
  15. Addict Biol. 2000 Apr 1;5(2):141-51 - PubMed
  16. Alcohol Clin Exp Res. 2006 Aug;30(8):1422-8 - PubMed
  17. Autoimmun Rev. 2008 Jul;7(7):567-73 - PubMed
  18. Am J Physiol Gastrointest Liver Physiol. 2011 Apr;300(4):G516-25 - PubMed
  19. Free Radic Biol Med. 2002 Jan 1;32(1):38-45 - PubMed
  20. Free Radic Biol Med. 2008 Aug 1;45(3):306-11 - PubMed
  21. Semin Liver Dis. 2004 Aug;24(3):273-87 - PubMed
  22. J Biol Chem. 2004 Dec 3;279(49):50949-55 - PubMed
  23. Hepatology. 1987 Nov-Dec;7(6):1210-4 - PubMed
  24. Hepatology. 2002 Dec;36(6):1478-87 - PubMed
  25. Alcohol Clin Exp Res. 2010 Dec;34(12):2126-36 - PubMed
  26. Nat Rev Immunol. 2006 Jul;6(7):508-19 - PubMed
  27. Clin Liver Dis. 2008 Nov;12(4):861-82, x - PubMed
  28. J Cell Biol. 2010 Jun 28;189(7):1059-70 - PubMed
  29. Exp Biol Med (Maywood). 2008 Mar;233(3):344-55 - PubMed
  30. Mol Pharmacol. 1999 Feb;55(2):223-33 - PubMed
  31. J Clin Invest. 2009 May;119(5):1335-49 - PubMed
  32. Hepatology. 2003 Feb;37(2):410-9 - PubMed
  33. Gut. 2001 Dec;49(6):852-9 - PubMed
  34. Alcohol Clin Exp Res. 2009 Feb;33(2):220-32 - PubMed
  35. Gastroenterology. 1993 Jul;105(1):254-66 - PubMed
  36. Semin Liver Dis. 2010 Aug;30(3):245-57 - PubMed
  37. J Hepatol. 2006 Aug;45(2):306-20 - PubMed
  38. Hepatology. 1994 Dec;20(6):1465-71 - PubMed
  39. Gastroenterology. 1996 Jul;111(1):206-16 - PubMed
  40. J Clin Invest. 2003 Jul;112(2):147-9 - PubMed
  41. Antioxid Redox Signal. 2011 Jul 15;15(2):523-34 - PubMed
  42. Hepatology. 1993 Jan;17(1):14-9 - PubMed
  43. Hepatology. 2001 Oct;34(4 Pt 1):729-37 - PubMed
  44. Free Radic Biol Med. 2005 Sep 1;39(5):619-30 - PubMed
  45. Hepatology. 2004 Jan;39(1):197-203 - PubMed
  46. Gut. 2008 Oct;57(10):1341-4 - PubMed
  47. Clin Exp Immunol. 2009 Oct;158(1):115-24 - PubMed
  48. Alcohol Clin Exp Res. 2007 Jan;31(1):122-9 - PubMed
  49. Lupus. 1995 Dec;4(6):486-90 - PubMed
  50. Nat Clin Pract Cardiovasc Med. 2008 Sep;5(9):531-40 - PubMed
  51. Hepatology. 2009 Dec;50(6):1809-17 - PubMed
  52. Am J Physiol Gastrointest Liver Physiol. 2004 Aug;287(2):G310-4 - PubMed
  53. Proc Nutr Soc. 2006 Aug;65(3):278-90 - PubMed
  54. Front Biosci. 1999 Jun 15;4:D533-40 - PubMed
  55. Hepatology. 2009 Feb;49(2):646-57 - PubMed
  56. Hepatology. 1993 Jan;17(1):9-13 - PubMed
  57. J Nutr. 2008 Oct;138(10):1872-9 - PubMed
  58. Hepatology. 2007 Nov;46(5):1519-29 - PubMed
  59. Curr Opin Immunol. 2008 Feb;20(1):68-74 - PubMed
  60. Nat Rev Immunol. 2006 Oct;6(10):772-83 - PubMed
  61. Gastroenterology. 1995 Jan;108(1):201-7 - PubMed
  62. Hepatology. 2000 Apr;31(4):878-84 - PubMed
  63. Gut. 2005 Jul;54(7):987-93 - PubMed
  64. Immunol Rev. 2008 Jun;223:143-55 - PubMed
  65. Int J Mol Med. 2010 Oct;26(4):471-6 - PubMed
  66. J Hepatol. 2006 Jan;44(1):183-9 - PubMed
  67. Am J Med. 1990 Aug;89(2):129-33 - PubMed
  68. Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):519-26 - PubMed
  69. Hepatology. 2003 Jul;38(1):42-9 - PubMed
  70. Proc Natl Acad Sci U S A. 1986 Oct;83(20):7923-7 - PubMed
  71. J Intern Med. 2000 Mar;247(3):371-80 - PubMed
  72. J Lipid Res. 2005 Jul;46(7):1353-63 - PubMed
  73. Curr Drug Targets. 2010 Apr;11(4):494-505 - PubMed
  74. Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G847-51 - PubMed
  75. Circ Res. 2011 Jan 21;108(2):235-48 - PubMed
  76. Metabolism. 2011 Mar;60(3):313-26 - PubMed
  77. Semin Liver Dis. 1993 May;13(2):183-95 - PubMed
  78. Am J Gastroenterol. 2008 Jan;103(1):147-53 - PubMed
  79. Autoimmun Rev. 2011 Aug;10(10):609-16 - PubMed
  80. Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L1-17 - PubMed

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