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Praveen EP, Sahoo J, Khurana ML, et al. Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance. Indian J Endocrinol Metab. 2012;16(1):105-11doi: 10.4103/2230-8210.91204.
Praveen, E. P., Sahoo, J., Khurana, M. L., Kulshreshtha, B., Khadgawat, R., Gupta, N., Dwivedi, S. N., Kumar, G., Prabhakaran, D., & Ammini, A. C. (2012). Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance. Indian journal of endocrinology and metabolism, 16(1), 105-11. https://doi.org/10.4103/2230-8210.91204
Praveen, Edavan P, et al. "Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance." Indian journal of endocrinology and metabolism vol. 16,1 (2012): 105-11. doi: https://doi.org/10.4103/2230-8210.91204
Praveen EP, Sahoo J, Khurana ML, Kulshreshtha B, Khadgawat R, Gupta N, Dwivedi SN, Kumar G, Prabhakaran D, Ammini AC. Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance. Indian J Endocrinol Metab. 2012 Jan;16(1):105-11. doi: 10.4103/2230-8210.91204. PMID: 22276260; PMCID: PMC3263177.
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Indian J Endocrinol Metab. 2012 Jan;16(1):105-11. doi: 10.4103/2230-8210.91204.

Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance.

Indian journal of endocrinology and metabolism

Edavan P Praveen, Jayaprakash Sahoo, Madan L Khurana, Bindu Kulshreshtha, Rajesh Khadgawat, Nandita Gupta, Sada Nand Dwivedi, Guresh Kumar, Dorairaj Prabhakaran, Ariachery C Ammini

Affiliations

  1. Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India.

PMID: 22276260 PMCID: PMC3263177 DOI: 10.4103/2230-8210.91204

Abstract

AIMS: The aim was to study the effect of family history of type 2 diabetes mellitus (T2DM) on insulin sensitivity and β-cell function in normoglycemic offspring.

MATERIAL AND METHODS: Offspring of T2DM patients (cases) and individuals without family history of T2DM (controls) were the subjects for this cross-sectional study. All participants underwent 75 g OGTT and samples were collected for plasma insulin, C-peptide, and proinsulin at 0, 30, 60, and 120 minutes.

RESULTS: A total of 271 cases (age 22 ± 10 years; 53% males) and 259 controls (28 ± 10 years, 66% males) were enrolled for the study. BMI, plasma insulin, C-peptide, proinsulin, HOMA-IR, and insulinogenic index (0-120) were significantly higher and whole-body insulin sensitivity (WBISI) and disposition index (0-120) [DI 120] were lower in cases compared to controls. After adjusting for BMI, proinsulin at 120 minutes, area under the curve (AUC) of proinsulin (during OGTT) and AUC proinsulin/AUC C-peptide were significantly higher in cases. Cases were subdivided into four groups according to inheritance pattern; paternal DM (PDM), maternal DM (MDM), grandparental DM (GPDM), and both parents DM (BPDM). The magnitude of differences varied with relationship (greater when both parents and grandparents were affected). Mean HOMA-IR was higher by 127% and 50% and DI 120 was lower by 33% and 18% (adjusted for age and gender) in the BPDM and GPDM groups respectively compared to controls.

CONCLUSIONS: We observed higher BMI, plasma insulin, C-peptide, and proinsulin and lower insulin sensitivity and β-cell compensation in normoglycemic offspring of T2DM subjects compared to controls. Differences were greater when both parents and grandparents had T2DM.

Keywords: grandparental history of DM; insulin sensitivity; normoglycemic; offspring of individuals with type 2 diabetes; β-cell function

References

  1. J Clin Endocrinol Metab. 2010 Oct;95(10):4703-11 - PubMed
  2. Diabetes. 2000 Dec;49(12):2201-7 - PubMed
  3. J Clin Endocrinol Metab. 1996 May;81(5):1846-51 - PubMed
  4. J Matern Fetal Med. 2000 Jan-Feb;9(1):83-8 - PubMed
  5. Diabetes. 1997 Jun;46(6):1001-9 - PubMed
  6. Diabetes Technol Ther. 2009 Jun;11(6):393-8 - PubMed
  7. Am J Clin Nutr. 2007 Jun;85(6):1643-9 - PubMed
  8. Metabolism. 1998 Aug;47(8):998-1004 - PubMed
  9. Diabetes Care. 1999 Aug;22(8):1325-9 - PubMed
  10. Diabetes Care. 2006 May;29(5):1130-9 - PubMed
  11. Diabetes. 1992 Dec;41(12):1575-86 - PubMed
  12. Diabetes Care. 2005 Jan;28(1):115-9 - PubMed
  13. Obesity (Silver Spring). 2008 Aug;16(8):1901-7 - PubMed
  14. N Engl J Med. 1988 Nov 17;319(20):1297-301 - PubMed
  15. Ann Intern Med. 1990 Dec 15;113(12):909-15 - PubMed
  16. Diabetes. 2002 Oct;51(10):3014-9 - PubMed
  17. Diabetes. 2002 Jul;51(7):2170-8 - PubMed
  18. Diabetes Care. 1998 Feb;21(2):278-82 - PubMed
  19. Diabetologia. 1999 Jan;42(1):24-7 - PubMed
  20. Diabetes Technol Ther. 2010 Sep;12(9):723-30 - PubMed
  21. Diabetes Care. 1994 Feb;17(2):152-4 - PubMed
  22. JAMA. 1995 Jun 21;273(23):1855-61 - PubMed
  23. Diabetes Care. 1995 Jul;18(7):1020-2 - PubMed
  24. Diabetes Care. 1999 Sep;22(9):1462-70 - PubMed
  25. Diabetes Care. 2007 Jun;30(6):1562-6 - PubMed
  26. Diabetes Care. 2004 Jan;27 Suppl 1:S5-S10 - PubMed
  27. Diabetologia. 2009 Nov;52(11):2435-2444 - PubMed
  28. Diabet Med. 1996 Nov;13(11):953-9 - PubMed
  29. J Clin Invest. 1999 Sep;104(6):787-94 - PubMed
  30. Diabetes. 2000 Dec;49(12):2094-101 - PubMed
  31. Diabetes. 2009 May;58(5):1212-21 - PubMed
  32. Diabetes Res Clin Pract. 2008 Nov;82(2):268-75 - PubMed
  33. Diabetologia. 1985 Jul;28(7):412-9 - PubMed
  34. PLoS One. 2010 Dec 02;5(12):e14194 - PubMed

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