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Mattioli L, Bracci A, Titomanlio F, et al. Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice. Evid Based Complement Alternat Med. 2012;2012:741925doi: 10.1155/2012/741925.
Mattioli, L., Bracci, A., Titomanlio, F., Perfumi, M., & De Feo, V. (2012). Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice. Evidence-based complementary and alternative medicine : eCAM, 2012741925. https://doi.org/10.1155/2012/741925
Mattioli, Laura, et al. "Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice." Evidence-based complementary and alternative medicine : eCAM vol. 2012 (2012): 741925. doi: https://doi.org/10.1155/2012/741925
Mattioli L, Bracci A, Titomanlio F, Perfumi M, De Feo V. Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice. Evid Based Complement Alternat Med. 2012;2012:741925. doi: 10.1155/2012/741925. Epub 2012 Feb 08. PMID: 22454681; PMCID: PMC3290905.
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Evid Based Complement Alternat Med. 2012;2012:741925. doi: 10.1155/2012/741925. Epub 2012 Feb 08.

Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice.

Evidence-based complementary and alternative medicine : eCAM

Laura Mattioli, Antonio Bracci, Federica Titomanlio, Marina Perfumi, Vincenzo De Feo

Affiliations

  1. Pharmacognosy Unit, School of Pharmacy, University of Camerino, Via Madonna delle Carceri 9, 62032 Camerino, Italy.

PMID: 22454681 PMCID: PMC3290905 DOI: 10.1155/2012/741925

Abstract

The aim of the present study was to investigate, in vivo, the effect of a Brugmansia arborea extract (BRU), chromatographic fractions (FA and FNA), and isolated alkaloids on the expression and the acquisition of morphine tolerance and dependence. Substances were acutely (for expression) or repeatedly (for acquisition) administered in mice treated with morphine twice daily for 5 or 6 days, in order to make them tolerant or dependent. Morphine tolerance was assessed using the tail-flick test at 1st and 5th days. Morphine dependence was evaluated through the manifestation of withdrawal symptoms induced by naloxone injection at 6th day. Results showed that BRU significantly reduced the expression of morphine tolerance, while it was ineffective to modulate its acquisition. Chromatographic fractions and pure alkaloids failed to reduce morphine tolerance. Conversely BRU, FA, and pure alkaloids administrations significantly attenuated both development and expression of morphine dependence. These data suggest that Brugmansia arborea Lagerh might have human therapeutic potential for treatment of opioid addiction.

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