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Shetty SR, Babu SG, Kumari S, et al. Malondialdehyde levels in oral sub mucous fibrosis: a clinicopathological and biochemical study. N Am J Med Sci. 2012;4(3):125-8doi: 10.4103/1947-2714.93887.
Shetty, S. R., Babu, S. G., Kumari, S., Rao, V., Vijay, R., & Karikal, A. (2012). Malondialdehyde levels in oral sub mucous fibrosis: a clinicopathological and biochemical study. North American journal of medical sciences, 4(3), 125-8. https://doi.org/10.4103/1947-2714.93887
Shetty, Shishir Ram, et al. "Malondialdehyde levels in oral sub mucous fibrosis: a clinicopathological and biochemical study." North American journal of medical sciences vol. 4,3 (2012): 125-8. doi: https://doi.org/10.4103/1947-2714.93887
Shetty SR, Babu SG, Kumari S, Rao V, Vijay R, Karikal A. Malondialdehyde levels in oral sub mucous fibrosis: a clinicopathological and biochemical study. N Am J Med Sci. 2012 Mar;4(3):125-8. doi: 10.4103/1947-2714.93887. PMID: 22454825; PMCID: PMC3309619.
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N Am J Med Sci. 2012 Mar;4(3):125-8. doi: 10.4103/1947-2714.93887.

Malondialdehyde levels in oral sub mucous fibrosis: a clinicopathological and biochemical study.

North American journal of medical sciences

Shishir Ram Shetty, Subhas G Babu, Suchetha Kumari, Vaman Rao, R Vijay, Arvind Karikal

Affiliations

  1. Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental Sciences, Mangalore, India.

PMID: 22454825 PMCID: PMC3309619 DOI: 10.4103/1947-2714.93887

Abstract

BACKGROUND: Oral submucous fibrosis is one of the most commonly occurring potentially malignant disorders in the South-East Asia. Levels of lipid peroxidation product malondialdehyde have been recently correlated with clinical grades of oral Submucous fibrosis.

AIMS: The aims of this study were to estimate the levels of malondialdehyde in serum, saliva and tissue in patients with oral submucous fibrosis, to correlate change in levels of malodialdehyde with the histopathological grading.

MATERIALS AND METHODS: The study group comprised of 65 clinically diagnosed and histopathologically confirmed cases of oral submucous fibrosis, 21 age and sex matched controls were also enrolled into the study. The serum saliva and tissue samples in the study groups were evaluated by the thiobarbutric acid reactive substances.

RESULTS: There was a significant difference between the serum and salivary malondialdehyde among the histopathological grades of oral submucous fibrosis. Tissue malonaldehyde levels were significantly higher as the grading progressed but tissue levels in grade 3 oral submucous fibrosis were lower than the controls.

CONCLUSION: This decrease in tissue malonaldehyde could possibly be associated to collagen cross linking occurring during the advanced stages of oral submucous fibrosis.

Keywords: Collagen; Cross-linking; Lipid peroxidation; Saliva; Serum; Tissue

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