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Irvine RE, Grove J, Toseland PA, et al. The effect of age on the hydroxylation of amylobarbitone sodium in man. Br J Clin Pharmacol. 1974;1(1):41-3doi: 10.1111/j.1365-2125.1974.tb00204.x.
Irvine, R. E., Grove, J., Toseland, P. A., & Trounce, J. R. (1974). The effect of age on the hydroxylation of amylobarbitone sodium in man. British journal of clinical pharmacology, 1(1), 41-3. https://doi.org/10.1111/j.1365-2125.1974.tb00204.x
Irvine, R E, et al. "The effect of age on the hydroxylation of amylobarbitone sodium in man." British journal of clinical pharmacology vol. 1,1 (1974): 41-3. doi: https://doi.org/10.1111/j.1365-2125.1974.tb00204.x
Irvine RE, Grove J, Toseland PA, Trounce JR. The effect of age on the hydroxylation of amylobarbitone sodium in man. Br J Clin Pharmacol. 1974 Feb;1(1):41-3. doi: 10.1111/j.1365-2125.1974.tb00204.x. PMID: 22454867; PMCID: PMC1402408.
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Br J Clin Pharmacol. 1974 Feb;1(1):41-3. doi: 10.1111/j.1365-2125.1974.tb00204.x.

The effect of age on the hydroxylation of amylobarbitone sodium in man.

British journal of clinical pharmacology

R E Irvine, J Grove, P A Toseland, J R Trounce

Affiliations

  1. St Helen's Hospital, Hastings.

PMID: 22454867 PMCID: PMC1402408 DOI: 10.1111/j.1365-2125.1974.tb00204.x

Abstract

1 Following a single oral dose of amylobarbitone sodium it has been shown that a group of young subjects convert a higher proportion of the dose to 3'-hydroxyamylobarbitone than a group of elderly subjects. 2 Twenty-four hours after the administration of the drug, the mean plasma level of amylobarbitone in the elderly group is significantly higher than in the group of young subjects. 3 It is concluded that the rate of hydroxylation of amylobarbitone sodium decreases with age.

References

  1. J Pharm Pharmacol. 1971 Dec;23(12):936-40 - PubMed
  2. Clin Chim Acta. 1970 Aug;29(2):253-60 - PubMed
  3. Br Med J. 1971 Sep 11;3(5775):607-9 - PubMed

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